Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance
Mouse and rats are staple model organisms that have been traditionally used for oncological studies; however, their short lifespan and highly prone to cancers limit their utilizationsin understanding the mechanisms of cancer resistance. In recent years, several studies of the non-standard long-lived...
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ftdatacite:10.6084/m9.figshare.12851897.v1 2023-05-15T15:36:01+02:00 Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance Jiang, Jian-Jun Qing-Peng Kong 2020 https://dx.doi.org/10.6084/m9.figshare.12851897.v1 https://tandf.figshare.com/articles/dataset/Comparative_analysis_of_long_noncoding_RNAs_in_long-lived_mammals_provides_insights_into_natural_cancer-resistance/12851897/1 unknown Taylor & Francis https://dx.doi.org/10.1080/15476286.2020.1792116 https://dx.doi.org/10.6084/m9.figshare.12851897 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Biophysics Medicine Genetics FOS Biological sciences Evolutionary Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified dataset Dataset 2020 ftdatacite https://doi.org/10.6084/m9.figshare.12851897.v1 https://doi.org/10.1080/15476286.2020.1792116 https://doi.org/10.6084/m9.figshare.12851897 2021-11-05T12:55:41Z Mouse and rats are staple model organisms that have been traditionally used for oncological studies; however, their short lifespan and highly prone to cancers limit their utilizationsin understanding the mechanisms of cancer resistance. In recent years, several studies of the non-standard long-lived mammalian species like naked mole rat (NMR) have provided new insights of mechanisms in natural anti-cancer. How long-lived species genetically maintain longevity and cancer-resistance remains largely elusive. To better understand the underlying anti-cancer mechanisms in long-lived mammals, we genome widely identified long noncoding RNA (lncRNA) transcripts of two longevous mammals, bowhead whale (BW, Balaena mysticetus ) and Brandt’s bat (BB, Myotis brandtii ) and featured their sequence traits, expression patterns, and their correlations with cancer-resistance. Similar with naked mole rat (NMR, Heterocephalus glaber ), the most long-lived rodent, BW and BB lncRNAs show low sequence conservation and dynamic expressions among tissues and physiological stages. By utilizing k-mers clustering, 75–136 of BW, BB and NMR lncRNAs were found in close relation (Pearson’s r ≥0.9, p r > 0.8 or r Abbreviations: BW: bowhead whale; BB: Brandt’s bat; NMR: naked mole rat; LLM: long-lived mammal; HTS: human tumour-suppressors; PTS: potential tumour suppressor; ARD: ageing related diseases; HAR-Lncs: lncRNAs that related with human ageing diseases; Kmer-lncs: lncRNAs in long-lived mammal species that corelated (Pearson’s r ≥0.9, p < 0.01) with the 10 HAR-Lncs by k-mers clustering; All-lncs: all the lncRNAs in long-lived mammal species; SDE-lncs: significant differentially expressed lncRNAs Dataset Balaena mysticetus bowhead whale DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Biophysics Medicine Genetics FOS Biological sciences Evolutionary Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified |
spellingShingle |
Biophysics Medicine Genetics FOS Biological sciences Evolutionary Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified Jiang, Jian-Jun Qing-Peng Kong Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance |
topic_facet |
Biophysics Medicine Genetics FOS Biological sciences Evolutionary Biology 39999 Chemical Sciences not elsewhere classified FOS Chemical sciences Ecology Immunology FOS Clinical medicine 69999 Biological Sciences not elsewhere classified |
description |
Mouse and rats are staple model organisms that have been traditionally used for oncological studies; however, their short lifespan and highly prone to cancers limit their utilizationsin understanding the mechanisms of cancer resistance. In recent years, several studies of the non-standard long-lived mammalian species like naked mole rat (NMR) have provided new insights of mechanisms in natural anti-cancer. How long-lived species genetically maintain longevity and cancer-resistance remains largely elusive. To better understand the underlying anti-cancer mechanisms in long-lived mammals, we genome widely identified long noncoding RNA (lncRNA) transcripts of two longevous mammals, bowhead whale (BW, Balaena mysticetus ) and Brandt’s bat (BB, Myotis brandtii ) and featured their sequence traits, expression patterns, and their correlations with cancer-resistance. Similar with naked mole rat (NMR, Heterocephalus glaber ), the most long-lived rodent, BW and BB lncRNAs show low sequence conservation and dynamic expressions among tissues and physiological stages. By utilizing k-mers clustering, 75–136 of BW, BB and NMR lncRNAs were found in close relation (Pearson’s r ≥0.9, p r > 0.8 or r Abbreviations: BW: bowhead whale; BB: Brandt’s bat; NMR: naked mole rat; LLM: long-lived mammal; HTS: human tumour-suppressors; PTS: potential tumour suppressor; ARD: ageing related diseases; HAR-Lncs: lncRNAs that related with human ageing diseases; Kmer-lncs: lncRNAs in long-lived mammal species that corelated (Pearson’s r ≥0.9, p < 0.01) with the 10 HAR-Lncs by k-mers clustering; All-lncs: all the lncRNAs in long-lived mammal species; SDE-lncs: significant differentially expressed lncRNAs |
format |
Dataset |
author |
Jiang, Jian-Jun Qing-Peng Kong |
author_facet |
Jiang, Jian-Jun Qing-Peng Kong |
author_sort |
Jiang, Jian-Jun |
title |
Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance |
title_short |
Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance |
title_full |
Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance |
title_fullStr |
Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance |
title_full_unstemmed |
Comparative analysis of long noncoding RNAs in long-lived mammals provides insights into natural cancer-resistance |
title_sort |
comparative analysis of long noncoding rnas in long-lived mammals provides insights into natural cancer-resistance |
publisher |
Taylor & Francis |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.12851897.v1 https://tandf.figshare.com/articles/dataset/Comparative_analysis_of_long_noncoding_RNAs_in_long-lived_mammals_provides_insights_into_natural_cancer-resistance/12851897/1 |
genre |
Balaena mysticetus bowhead whale |
genre_facet |
Balaena mysticetus bowhead whale |
op_relation |
https://dx.doi.org/10.1080/15476286.2020.1792116 https://dx.doi.org/10.6084/m9.figshare.12851897 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.12851897.v1 https://doi.org/10.1080/15476286.2020.1792116 https://doi.org/10.6084/m9.figshare.12851897 |
_version_ |
1766366349189185536 |