Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy
Additional file 5: Figure S4. The terminal 14 amino acids of TNNT1 are absolutely conserved across multiple mammalian species. Clustal Omega alignment of TNNT1 amino acid sequences across 6 different mammalian species. The exons that encode each region of the protein are labelled. Of note, exon 14 e...
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ftdatacite:10.6084/m9.figshare.12838629.v1 2023-05-15T15:50:10+02:00 Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy Clayton, Joshua S. Elyshia L. McNamara Goullee, Hayley Conijn, Stefan Muthsam, Keren Musk, Gabrielle C. Coote, David Kijas, James Testa, Alison C. Taylor, Rhonda L. O’Hara, Amanda J. Groth, David Ottenheijm, Coen Ravenscroft, Gianina Laing, Nigel G. Nowak, Kristen J. 2020 https://dx.doi.org/10.6084/m9.figshare.12838629.v1 https://springernature.figshare.com/articles/Additional_file_5_of_Ovine_congenital_progressive_muscular_dystrophy_OCPMD_is_a_model_of_TNNT1_congenital_myopathy/12838629/1 unknown figshare https://dx.doi.org/10.1186/s40478-020-01017-1 https://dx.doi.org/10.6084/m9.figshare.12838629 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Genetics FOS Biological sciences Molecular Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified Text article-journal Journal contribution ScholarlyArticle 2020 ftdatacite https://doi.org/10.6084/m9.figshare.12838629.v1 https://doi.org/10.1186/s40478-020-01017-1 https://doi.org/10.6084/m9.figshare.12838629 2021-11-05T12:55:41Z Additional file 5: Figure S4. The terminal 14 amino acids of TNNT1 are absolutely conserved across multiple mammalian species. Clustal Omega alignment of TNNT1 amino acid sequences across 6 different mammalian species. The exons that encode each region of the protein are labelled. Of note, exon 14 encodes the terminal 14 amino acids of TNNT1, which produce an intrinsically disordered domain that binds to tropomyosin [34]. Protein sequences used for alignments were as follows: sheep (Ovis aries): AMR55385 (published AA sequence from K218690 CDS), human (Homo sapiens): NP_0011196044 (NCBI RefSeq), cow (Bos taurus): NP_776899 (NCBI RefSeq), mouse (Mus musculus): NP_001264833 (NCBI RefSeq), rat (Rattus norvegicus): NP_001264191 (NCBI RefSeq), and dog (Canis lupus familiaris): XP_005616225 (NCBI predicted). Text Canis lupus DataCite Metadata Store (German National Library of Science and Technology) |
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Open Polar |
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DataCite Metadata Store (German National Library of Science and Technology) |
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topic |
Genetics FOS Biological sciences Molecular Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified |
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Genetics FOS Biological sciences Molecular Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified Clayton, Joshua S. Elyshia L. McNamara Goullee, Hayley Conijn, Stefan Muthsam, Keren Musk, Gabrielle C. Coote, David Kijas, James Testa, Alison C. Taylor, Rhonda L. O’Hara, Amanda J. Groth, David Ottenheijm, Coen Ravenscroft, Gianina Laing, Nigel G. Nowak, Kristen J. Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy |
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Genetics FOS Biological sciences Molecular Biology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences 69999 Biological Sciences not elsewhere classified |
description |
Additional file 5: Figure S4. The terminal 14 amino acids of TNNT1 are absolutely conserved across multiple mammalian species. Clustal Omega alignment of TNNT1 amino acid sequences across 6 different mammalian species. The exons that encode each region of the protein are labelled. Of note, exon 14 encodes the terminal 14 amino acids of TNNT1, which produce an intrinsically disordered domain that binds to tropomyosin [34]. Protein sequences used for alignments were as follows: sheep (Ovis aries): AMR55385 (published AA sequence from K218690 CDS), human (Homo sapiens): NP_0011196044 (NCBI RefSeq), cow (Bos taurus): NP_776899 (NCBI RefSeq), mouse (Mus musculus): NP_001264833 (NCBI RefSeq), rat (Rattus norvegicus): NP_001264191 (NCBI RefSeq), and dog (Canis lupus familiaris): XP_005616225 (NCBI predicted). |
format |
Text |
author |
Clayton, Joshua S. Elyshia L. McNamara Goullee, Hayley Conijn, Stefan Muthsam, Keren Musk, Gabrielle C. Coote, David Kijas, James Testa, Alison C. Taylor, Rhonda L. O’Hara, Amanda J. Groth, David Ottenheijm, Coen Ravenscroft, Gianina Laing, Nigel G. Nowak, Kristen J. |
author_facet |
Clayton, Joshua S. Elyshia L. McNamara Goullee, Hayley Conijn, Stefan Muthsam, Keren Musk, Gabrielle C. Coote, David Kijas, James Testa, Alison C. Taylor, Rhonda L. O’Hara, Amanda J. Groth, David Ottenheijm, Coen Ravenscroft, Gianina Laing, Nigel G. Nowak, Kristen J. |
author_sort |
Clayton, Joshua S. |
title |
Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy |
title_short |
Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy |
title_full |
Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy |
title_fullStr |
Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy |
title_full_unstemmed |
Additional file 5 of Ovine congenital progressive muscular dystrophy (OCPMD) is a model of TNNT1 congenital myopathy |
title_sort |
additional file 5 of ovine congenital progressive muscular dystrophy (ocpmd) is a model of tnnt1 congenital myopathy |
publisher |
figshare |
publishDate |
2020 |
url |
https://dx.doi.org/10.6084/m9.figshare.12838629.v1 https://springernature.figshare.com/articles/Additional_file_5_of_Ovine_congenital_progressive_muscular_dystrophy_OCPMD_is_a_model_of_TNNT1_congenital_myopathy/12838629/1 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
https://dx.doi.org/10.1186/s40478-020-01017-1 https://dx.doi.org/10.6084/m9.figshare.12838629 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.12838629.v1 https://doi.org/10.1186/s40478-020-01017-1 https://doi.org/10.6084/m9.figshare.12838629 |
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1766385149724852224 |