Antiproliferative activity of carotenoid pigments produced by extremophile bacteria
Various microorganisms are able to synthesize pigments, which usually present antioxidant properties. The aim of this work was to evaluate the antiproliferative activity of bacterial pigments against cancer cells Neuro-2a, Saos-2 and MCF-7. Pigments were obtained from Deinococcus sp. UDEC-P1 and Art...
Main Authors: | , , , , , , |
---|---|
Format: | Other Non-Article Part of Journal/Newspaper |
Language: | unknown |
Published: |
Taylor & Francis
2019
|
Subjects: | |
Online Access: | https://dx.doi.org/10.6084/m9.figshare.11338916 https://tandf.figshare.com/articles/journal_contribution/Antiproliferative_activity_of_carotenoid_pigments_produced_by_extremophile_bacteria/11338916 |
id |
ftdatacite:10.6084/m9.figshare.11338916 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.6084/m9.figshare.11338916 2023-05-15T13:45:33+02:00 Antiproliferative activity of carotenoid pigments produced by extremophile bacteria Tapia, Cristian López, Bárbara Astuya, Allisson Becerra, José Gugliandolo, Concetta Parra, Boris Martínez, Miguel 2019 https://dx.doi.org/10.6084/m9.figshare.11338916 https://tandf.figshare.com/articles/journal_contribution/Antiproliferative_activity_of_carotenoid_pigments_produced_by_extremophile_bacteria/11338916 unknown Taylor & Francis https://dx.doi.org/10.1080/14786419.2019.1698574 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY Biochemistry Medicine Microbiology FOS Biological sciences Cell Biology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Cancer Journal contribution article-journal Text ScholarlyArticle 2019 ftdatacite https://doi.org/10.6084/m9.figshare.11338916 https://doi.org/10.1080/14786419.2019.1698574 2022-02-08T13:57:03Z Various microorganisms are able to synthesize pigments, which usually present antioxidant properties. The aim of this work was to evaluate the antiproliferative activity of bacterial pigments against cancer cells Neuro-2a, Saos-2 and MCF-7. Pigments were obtained from Deinococcus sp. UDEC-P1 and Arthrobacter sp. UDEC-A13. Both bacterial strains were isolated from cold environments (Patagonia and Antarctica, respectively). Pigments were purified and analyzed by HPLC. Antiproliferative activity was evaluated by 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium (MTT) assay. Deinoxanthin carotenoid obtained from Deinococcus sp. UDEC-P1 was able to reduce significatively the viability of Saos-2 (37.1%), while no effect was observed against MCF-7 and Neuro-2a. Pigments obtained from Arthrobacter sp. UDEC-A13 showed a significant viability reduction of three tumour cells (20.6% Neuro-2a, 26.3% Saos-2 and 13.2% MCF-7). Therefore, carotenoid pigments produced by extremophilic bacteria Deinococcus sp. UDEC-P1 and Arthrobacter sp. UDEC-A13 could be proposed as novel complementary compounds in anticancer chemotherapy. Other Non-Article Part of Journal/Newspaper Antarc* Antarctica DataCite Metadata Store (German National Library of Science and Technology) Patagonia |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
Biochemistry Medicine Microbiology FOS Biological sciences Cell Biology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Cancer |
spellingShingle |
Biochemistry Medicine Microbiology FOS Biological sciences Cell Biology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Cancer Tapia, Cristian López, Bárbara Astuya, Allisson Becerra, José Gugliandolo, Concetta Parra, Boris Martínez, Miguel Antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
topic_facet |
Biochemistry Medicine Microbiology FOS Biological sciences Cell Biology Biotechnology 59999 Environmental Sciences not elsewhere classified FOS Earth and related environmental sciences Ecology Cancer |
description |
Various microorganisms are able to synthesize pigments, which usually present antioxidant properties. The aim of this work was to evaluate the antiproliferative activity of bacterial pigments against cancer cells Neuro-2a, Saos-2 and MCF-7. Pigments were obtained from Deinococcus sp. UDEC-P1 and Arthrobacter sp. UDEC-A13. Both bacterial strains were isolated from cold environments (Patagonia and Antarctica, respectively). Pigments were purified and analyzed by HPLC. Antiproliferative activity was evaluated by 3-4,5-dimethylthiazol-2-yl-2,5-diphenyltetrazolium (MTT) assay. Deinoxanthin carotenoid obtained from Deinococcus sp. UDEC-P1 was able to reduce significatively the viability of Saos-2 (37.1%), while no effect was observed against MCF-7 and Neuro-2a. Pigments obtained from Arthrobacter sp. UDEC-A13 showed a significant viability reduction of three tumour cells (20.6% Neuro-2a, 26.3% Saos-2 and 13.2% MCF-7). Therefore, carotenoid pigments produced by extremophilic bacteria Deinococcus sp. UDEC-P1 and Arthrobacter sp. UDEC-A13 could be proposed as novel complementary compounds in anticancer chemotherapy. |
format |
Other Non-Article Part of Journal/Newspaper |
author |
Tapia, Cristian López, Bárbara Astuya, Allisson Becerra, José Gugliandolo, Concetta Parra, Boris Martínez, Miguel |
author_facet |
Tapia, Cristian López, Bárbara Astuya, Allisson Becerra, José Gugliandolo, Concetta Parra, Boris Martínez, Miguel |
author_sort |
Tapia, Cristian |
title |
Antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
title_short |
Antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
title_full |
Antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
title_fullStr |
Antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
title_full_unstemmed |
Antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
title_sort |
antiproliferative activity of carotenoid pigments produced by extremophile bacteria |
publisher |
Taylor & Francis |
publishDate |
2019 |
url |
https://dx.doi.org/10.6084/m9.figshare.11338916 https://tandf.figshare.com/articles/journal_contribution/Antiproliferative_activity_of_carotenoid_pigments_produced_by_extremophile_bacteria/11338916 |
geographic |
Patagonia |
geographic_facet |
Patagonia |
genre |
Antarc* Antarctica |
genre_facet |
Antarc* Antarctica |
op_relation |
https://dx.doi.org/10.1080/14786419.2019.1698574 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.6084/m9.figshare.11338916 https://doi.org/10.1080/14786419.2019.1698574 |
_version_ |
1766227339286413312 |