In vivo Study of the Effects of a Northern Contaminant Mixture (NCM) on the Development of Metabolic and Cardiovascular Diseases under Conditions Typifying the Diets and Lifestyles of Northerners

• Main Authors: Jin, Xiaolei, Li, Nanqin, Ratnayake, Nimal, Willmore, William
• Format: Dataset
• Language: English
• Published: Canadian Cryospheric Information Network 2015
• Subjects: Diet; Disease; Heavy metal; Lifestyle; Methylmercury; Persistent organic pollutants POPs; Northern Contaminants Program; inuit
• Online Access: https://dx.doi.org/10.5443/12422; https://www.polardata.ca/pdcsearch/?doi_id=12422

This is a toxicological study using animal models. In this study, obese and lean JCR rats are treated orally with alcohol or high fat/sugar diet and a mixture of 22 contaminants found in the Inuit blood. After four weeks of daily dosing, the animals were sacrificed. Blood, urine, and organs were collected and analyzed for contaminant levels, lipid profile, and markers of organ toxicity, cardiovascular and metabolic diseases. : Purpose: To investigate the potential role of exposure to Northern contaminants in the development of metabolic and cardiovascular diseases using rodent models of human disease, the obese and lean JCR rats, as well as to examine the influence of genetic background such as obese versus lean, diet such as high fat/sugar vs normal nutritious diet, and lifestyle factors such as alcohol on the health effects of Northern contaminants. : Summary: Not Applicable