Mitochondrial responses to long-term and cyclic hypoxia depend on the oxidized fuel in a hypoxia-tolerant marine bivalve Crassostrea gigas ...

• Main Authors: Linda, Adzigbli, Ponsuksili, Siriluck, Inna, Sokolova
• Format: Dataset
• Language: English
• Published: Zenodo 2023
• Subjects: Constant hypoxia; Cyclic hypoxia; Mitochondria; Oxidative stress; Bioenergetics; Crassostrea gigas
• Online Access: https://dx.doi.org/10.5281/zenodo.8363328; https://zenodo.org/record/8363328

These are the metadata for a publication "Mitochondrial responses to long-term and cyclic hypoxia depend on the oxidized fuel in a hypoxia-tolerant marine bivalve Crassostrea gigas" under consideration for publication in the Scientific reports. Sessile benthic organisms like oysters inhabits intertidal zone transitioning between aquatic and terrestrial condition during tidal movements exposing the organisms to alternating hypoxia and reoxygenation (H/R) episodes thereby altering the respiratory chain activities and metabolome compositions. Our study investigated the effects of constant long-term H/R stress (90 min at ~0% O 2, and 10 min reoxygenation) and constant cyclic H/R stress (5 cycles of 15 min at ~0% O 2, and 10 min reoxygenation) on isolated mitochondria from the gill and the digestive gland of C. gigas respiring on different substrates (pyruvate, palmitate, and succinate). Both gill and the digestive gland mitochondria exposed to constant long-term H/R suppressed OXPHOS respiration especially ...