FLUORIDE INDUCED TOXICITY ON AMINO ACID, DNA AND RNA OF RAT, RATTUS RATTUS (WISTAR)

• Main Author: Dipali Pillewar
• Format: Text
• Language: unknown
• Published: Zenodo 2020
• Subjects: Sodium fluoride, Liver, DNA, RNA, Amino Acid.; 10.5281/zenodo.3612329; Davidson; Giles; Kayak; Verma; Rattus rattus
• Online Access: https://dx.doi.org/10.5281/zenodo.3612329; https://zenodo.org/record/3612329

Fluoride is a naturally occurring contaminant in the water and it is essential for normal maintenance of teeth and bones. However, prolonged exposure to high concentration of fluoride is found to be deleterious to teeth, bones, and other organs. In the present study, the effects of sodium fluoride induced toxicity in rat liver were evaluated. Twenty rats were divided into four experimental groups containing 5 rats each. 1st group was used for control and 2nd, 3rd and 4th groups were ingested with different concentrations of sodium fluoride water respectively for 56 days. The result of the present study was showed as significantly increased in total amino acid and free amino acid concentration along with a decreased in DNA and RNA content of the rat as compared to control. : {"references": ["Basha, S.K., & Rao, K.J. (2014). Sodium Fluoride Induced Histopathalogical Changes in Liver and Kidney of Albino Mice. Acta Chimica and Pharmaceutica Indica, 4, 58-62", "Giles, S.E. (1999). Kayak loading device employing guiding rollers and roof rack attachment mechanism: Google Patents.", "Grundy, S., Dobson, H.L., & Griffin, A.C. (1958). In vitro effect of surface active agents on human serum lipoprotein and protein patterns. Proceedings of the Society for Experimental Biology and Medicine, 98(2), 313-315.", "Holland, R.I. (1979). Fluoride inhibition of protein and DNA synthesis in cells in vitro. Acta pharmacologica et Toxicologica, 45(2), 96-101.", "Mejboum, W. (1939). As cited by Swift, H. The nucleic acids, Chargaff, E. and Davidson, JN Eds, 2, 51.", "Rymar, S.N. (1974). Effect of sodium fluoride on glutamine synthesis in the rat liver. Gigiena i Sanitariia (6), 114.", "Shashi, A., Singh, J., & Thapar, S. (1994). Effect of long-term administration of fluoride on levels of protein, free amino acids and RNA in rabbit brain. Fluoride, 27, 155-155.", "Shashi, A., & Thapar, S. (2001). Histopathology of fluoride-induced hepatotoxicity in rabbits. Fluoride, 34(1), 34-42.", "Shulman, J.D., & Wells, L.M. (1997). Acute fluoride toxicity from ingesting home\u2010use dental products in children, birth to 6 years of age. Journal of Public Health Dentistry, 57(3), 150-158.", "Susheela, A., & Bhatnagar, M. (2002). Reversal of fluoride induced cell injury through elimination of fluoride and consumption of diet rich in essential nutrients and antioxidants Oxygen/Nitrogen Radicals: Cell Injury and Disease, 335-340.", "Temple, M.D., Perrone, G.G., & Dawes, I.W. (2005). Complex cellular responses to reactive oxygen species. Trends in Cell Biology, 15(6), 319-326.", "Verma, R., Trivedi, M., & Chinoy, N. (2007). Black tea amelioration of sodium fluoride-induced alterations of DNA, RNA, and protein contents in the cerebral hemisphere, cerebellum, and medulla oblongata regions of mouse brain. Fluoride, 40(1), 7.", "Whitford, G.M. (1983). Fluorides: metabolism, mechanisms of action and safety. Dental hygiene, 57(5), 16-18, 20.", "Whittam, R., & Chipperfield, A.R. (1973). Ouabain binding to the sodium pump in plasma membranes isolated from ox brain. Biochimica et Biophysica Acta (BBA)-Biomembranes, 307(3), 563-577.", "Wiseman, A. (1970). Effect of inorganic fluoride on enzymes Pharmacology of Fluorides, 48-97.", "Zhan, X.A., Wang, M., Xu, Z.R., Li, J.X., & Li, J. (2006). Toxic effects of fluoride on kidney function and histological structure in young pigs. Fluoride, 39(1), 22-26."]}