Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ...
(Uploaded by Plazi for the Bat Literature Project) Bokeloh bat lyssavirus (BBLV), a novel lyssavirus, was isolated from a Natterer's bat ( Myotis nattererii ), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and...
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ftdatacite:10.5281/zenodo.13442301 2024-09-15T18:19:06+00:00 Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... Nolden, Tobias Banyard, Ashley C. Finke, Stefan Fooks, Anthony R. Hanke, Dennis Höper, Dirk Horton, Daniel L. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens P. Freuling, Conrad M. 2014 https://dx.doi.org/10.5281/zenodo.13442301 https://zenodo.org/doi/10.5281/zenodo.13442301 unknown Zenodo hash://md5/14ee6a1ceb65f31c1f677ad19d73d638 hash://sha256/136c44e044a33be521d10732370262496ef2b1340d43faa4705aa35de8f084a2 zotero://select/groups/5435545/items/P23KWLA4 https://zotero.org/groups/5435545/items/P23KWLA4 https://linker.bio/cut:hash://md5/0d1fe92990a8beb102536bb51f732cdb!/b231965-234428 hash://md5/26f7ce5dd404e33c6570edd4ba250d20 hash://md5/14ee6a1ceb65f31c1f677ad19d73d638 hash://sha256/136c44e044a33be521d10732370262496ef2b1340d43faa4705aa35de8f084a2 zotero://select/groups/5435545/items/P23KWLA4 https://zotero.org/groups/5435545/items/P23KWLA4 https://linker.bio/cut:hash://md5/0d1fe92990a8beb102536bb51f732cdb!/b231965-234428 hash://md5/26f7ce5dd404e33c6570edd4ba250d20 https://dx.doi.org/10.5281/zenodo.1410543 https://dx.doi.org/10.5281/zenodo.13442300 Biodiversity Mammalia Chiroptera Chordata Animalia bats bat JournalArticle ScholarlyArticle article-journal 2014 ftdatacite https://doi.org/10.5281/zenodo.1344230110.5281/zenodo.141054310.5281/zenodo.13442300 2024-09-02T10:15:12Z (Uploaded by Plazi for the Bat Literature Project) Bokeloh bat lyssavirus (BBLV), a novel lyssavirus, was isolated from a Natterer's bat ( Myotis nattererii ), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization both in vitro and in vivo was required to assess pathogenicity and vaccine protection. Full genome sequence analysis and antigenic cartography demonstrated that the German BBLV isolates are most closely related to European bat lyssavirus type 2 (EBLV-2) and Khujand virus and can be characterized within phylogroup I. In vivo characterization demonstrated that BBLV was pathogenic in mice when inoculated peripherally causing clinical signs typical for rabies encephalitis, with higher pathogenicity observed in juvenile mice. A limited vaccination-challenge experiment in mice was conducted and suggested that current vaccines would afford some protection against BBLV ... Article in Journal/Newspaper Natterer's bat DataCite |
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Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
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Biodiversity Mammalia Chiroptera Chordata Animalia bats bat Nolden, Tobias Banyard, Ashley C. Finke, Stefan Fooks, Anthony R. Hanke, Dennis Höper, Dirk Horton, Daniel L. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens P. Freuling, Conrad M. Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... |
topic_facet |
Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
description |
(Uploaded by Plazi for the Bat Literature Project) Bokeloh bat lyssavirus (BBLV), a novel lyssavirus, was isolated from a Natterer's bat ( Myotis nattererii ), a chiropteran species with a widespread and abundant distribution across Europe. As a novel lyssavirus, the risks of BBLV to animal and human health are unknown and as such characterization both in vitro and in vivo was required to assess pathogenicity and vaccine protection. Full genome sequence analysis and antigenic cartography demonstrated that the German BBLV isolates are most closely related to European bat lyssavirus type 2 (EBLV-2) and Khujand virus and can be characterized within phylogroup I. In vivo characterization demonstrated that BBLV was pathogenic in mice when inoculated peripherally causing clinical signs typical for rabies encephalitis, with higher pathogenicity observed in juvenile mice. A limited vaccination-challenge experiment in mice was conducted and suggested that current vaccines would afford some protection against BBLV ... |
format |
Article in Journal/Newspaper |
author |
Nolden, Tobias Banyard, Ashley C. Finke, Stefan Fooks, Anthony R. Hanke, Dennis Höper, Dirk Horton, Daniel L. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens P. Freuling, Conrad M. |
author_facet |
Nolden, Tobias Banyard, Ashley C. Finke, Stefan Fooks, Anthony R. Hanke, Dennis Höper, Dirk Horton, Daniel L. Mettenleiter, Thomas C. Müller, Thomas Teifke, Jens P. Freuling, Conrad M. |
author_sort |
Nolden, Tobias |
title |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... |
title_short |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... |
title_full |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... |
title_fullStr |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... |
title_full_unstemmed |
Comparative studies on the genetic, antigenic and pathogenic characteristics of Bokeloh bat lyssavirus ... |
title_sort |
comparative studies on the genetic, antigenic and pathogenic characteristics of bokeloh bat lyssavirus ... |
publisher |
Zenodo |
publishDate |
2014 |
url |
https://dx.doi.org/10.5281/zenodo.13442301 https://zenodo.org/doi/10.5281/zenodo.13442301 |
genre |
Natterer's bat |
genre_facet |
Natterer's bat |
op_relation |
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op_doi |
https://doi.org/10.5281/zenodo.1344230110.5281/zenodo.141054310.5281/zenodo.13442300 |
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1810457203436421120 |