Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ...
(Uploaded by Plazi for the Bat Literature Project) The emergence of several bat coronavirus-related disease outbreaks in human and domestic animals has fueled surveillance of coronaviruses in bats worldwide. However, little is known about how these viruses interact with their natural hosts. We demon...
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Online Access: | https://dx.doi.org/10.5281/zenodo.13441955 https://zenodo.org/doi/10.5281/zenodo.13441955 |
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ftdatacite:10.5281/zenodo.13441955 2024-09-15T18:30:36+00:00 Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... Mols, Vera C. Lamers, Mart M. Leijten, Lonneke Me. Breugem, Tim I. Van De Bildt, Marco Wg. Van Den Doel, Petra B. Lina, Peter Hc. Koopmans, Marion Pg. Haagmans, Bart L. Kuiken, Thijs Begeman, Lineke Gallagher, Tom 2023 https://dx.doi.org/10.5281/zenodo.13441955 https://zenodo.org/doi/10.5281/zenodo.13441955 unknown Zenodo hash://md5/cd8473843c5ca5e1901ed8f83e69ccc9 hash://sha256/b9880edf23200766f16b3e14e4bbc636a8f7ed605a8208190d5235aa75c0a3e9 zotero://select/groups/5435545/items/6JT2V95Q https://zotero.org/groups/5435545/items/6JT2V95Q https://linker.bio/cut:hash://md5/8a7cef80dea516fb6ea8f803ae126cf9!/b300974-303423 hash://md5/26f7ce5dd404e33c6570edd4ba250d20 hash://md5/cd8473843c5ca5e1901ed8f83e69ccc9 hash://sha256/b9880edf23200766f16b3e14e4bbc636a8f7ed605a8208190d5235aa75c0a3e9 zotero://select/groups/5435545/items/6JT2V95Q https://zotero.org/groups/5435545/items/6JT2V95Q https://linker.bio/cut:hash://md5/8a7cef80dea516fb6ea8f803ae126cf9!/b300974-303423 hash://md5/26f7ce5dd404e33c6570edd4ba250d20 https://dx.doi.org/10.5281/zenodo.1410543 https://dx.doi.org/10.5281/zenodo.13441956 Biodiversity Mammalia Chiroptera Chordata Animalia bats bat JournalArticle ScholarlyArticle article-journal 2023 ftdatacite https://doi.org/10.5281/zenodo.1344195510.5281/zenodo.141054310.5281/zenodo.13441956 2024-09-02T10:15:12Z (Uploaded by Plazi for the Bat Literature Project) The emergence of several bat coronavirus-related disease outbreaks in human and domestic animals has fueled surveillance of coronaviruses in bats worldwide. However, little is known about how these viruses interact with their natural hosts. We demonstrate a Betacoronavirus (subgenus Merbecovirus), PN-bCoV, in the intestine of its natural host, Nathusius's Pipistrelle Bat (Pipistrellus nathusii), by combining molecular and microscopy techniques. Eighty-eight P. nathusii bat carcasses were tested for PN-bCoV RNA by RT-qPCR, of which 25 bats (28%) tested positive. PN-bCoV RNA was more often detected in samples of the intestinal tract than in other sample types. In addition, viral RNA loads were higher in intestinal samples compared to other sample types, both on average and in each individual bat. In one bat, we demonstrated Merbecovirus antigen and PN-bCoV RNA expression in intestinal epithelium and the underlying connective tissue using immunohistochemistry ... Article in Journal/Newspaper Pipistrellus nathusii DataCite |
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Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
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Biodiversity Mammalia Chiroptera Chordata Animalia bats bat Mols, Vera C. Lamers, Mart M. Leijten, Lonneke Me. Breugem, Tim I. Van De Bildt, Marco Wg. Van Den Doel, Petra B. Lina, Peter Hc. Koopmans, Marion Pg. Haagmans, Bart L. Kuiken, Thijs Begeman, Lineke Gallagher, Tom Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
topic_facet |
Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
description |
(Uploaded by Plazi for the Bat Literature Project) The emergence of several bat coronavirus-related disease outbreaks in human and domestic animals has fueled surveillance of coronaviruses in bats worldwide. However, little is known about how these viruses interact with their natural hosts. We demonstrate a Betacoronavirus (subgenus Merbecovirus), PN-bCoV, in the intestine of its natural host, Nathusius's Pipistrelle Bat (Pipistrellus nathusii), by combining molecular and microscopy techniques. Eighty-eight P. nathusii bat carcasses were tested for PN-bCoV RNA by RT-qPCR, of which 25 bats (28%) tested positive. PN-bCoV RNA was more often detected in samples of the intestinal tract than in other sample types. In addition, viral RNA loads were higher in intestinal samples compared to other sample types, both on average and in each individual bat. In one bat, we demonstrated Merbecovirus antigen and PN-bCoV RNA expression in intestinal epithelium and the underlying connective tissue using immunohistochemistry ... |
format |
Article in Journal/Newspaper |
author |
Mols, Vera C. Lamers, Mart M. Leijten, Lonneke Me. Breugem, Tim I. Van De Bildt, Marco Wg. Van Den Doel, Petra B. Lina, Peter Hc. Koopmans, Marion Pg. Haagmans, Bart L. Kuiken, Thijs Begeman, Lineke Gallagher, Tom |
author_facet |
Mols, Vera C. Lamers, Mart M. Leijten, Lonneke Me. Breugem, Tim I. Van De Bildt, Marco Wg. Van Den Doel, Petra B. Lina, Peter Hc. Koopmans, Marion Pg. Haagmans, Bart L. Kuiken, Thijs Begeman, Lineke Gallagher, Tom |
author_sort |
Mols, Vera C. |
title |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_short |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_full |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_fullStr |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_full_unstemmed |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_sort |
intestinal tropism of a betacoronavirus (merbecovirus)in nathusius's pipistrelle bat (pipistrellus nathusii), its natural host ... |
publisher |
Zenodo |
publishDate |
2023 |
url |
https://dx.doi.org/10.5281/zenodo.13441955 https://zenodo.org/doi/10.5281/zenodo.13441955 |
genre |
Pipistrellus nathusii |
genre_facet |
Pipistrellus nathusii |
op_relation |
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op_doi |
https://doi.org/10.5281/zenodo.1344195510.5281/zenodo.141054310.5281/zenodo.13441956 |
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1810472066854420480 |