Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ...
(Uploaded by Plazi for the Bat Literature Project) The emergence of several bat coronavirus-related disease outbreaks in human and domestic animals has fueled surveillance of coronaviruses in bats worldwide. However, little is known about how these viruses interact with their natural hosts. We demon...
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Online Access: | https://dx.doi.org/10.5281/zenodo.13439961 https://zenodo.org/doi/10.5281/zenodo.13439961 |
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ftdatacite:10.5281/zenodo.13439961 2024-09-15T18:30:36+00:00 Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... Mols, Ara Lamers, Mart M. Leijten, Lonneke Me. 2023 https://dx.doi.org/10.5281/zenodo.13439961 https://zenodo.org/doi/10.5281/zenodo.13439961 unknown Zenodo hash://md5/cd7ab61b1f05c8c7ef1a6220f4b6e1a0 hash://sha256/fd8933d03467db28b6e16ec28311cffe89504954e19f27c0558d04a4c3cca4bb zotero://select/groups/5435545/items/XRH8KBYT https://zotero.org/groups/5435545/items/XRH8KBYT https://linker.bio/cut:hash://md5/4633afe70f65c8364976d86e95752638!/b184277-186737 hash://md5/26f7ce5dd404e33c6570edd4ba250d20 hash://md5/cd7ab61b1f05c8c7ef1a6220f4b6e1a0 hash://sha256/fd8933d03467db28b6e16ec28311cffe89504954e19f27c0558d04a4c3cca4bb zotero://select/groups/5435545/items/XRH8KBYT https://zotero.org/groups/5435545/items/XRH8KBYT https://linker.bio/cut:hash://md5/4633afe70f65c8364976d86e95752638!/b184277-186737 hash://md5/26f7ce5dd404e33c6570edd4ba250d20 https://dx.doi.org/10.5281/zenodo.1410543 https://dx.doi.org/10.5281/zenodo.13439962 Biodiversity Mammalia Chiroptera Chordata Animalia bats bat JournalArticle ScholarlyArticle article-journal 2023 ftdatacite https://doi.org/10.5281/zenodo.1343996110.5281/zenodo.141054310.5281/zenodo.13439962 2024-09-02T10:14:17Z (Uploaded by Plazi for the Bat Literature Project) The emergence of several bat coronavirus-related disease outbreaks in human and domestic animals has fueled surveillance of coronaviruses in bats worldwide. However, little is known about how these viruses interact with their natural hosts. We demonstrate a Betacoronavirus (subgenus Merbecovirus), PN-bCoV, in the intestine of its natural host, Nathusius's Pipistrelle Bat (Pipistrellus nathusii), by combining molecular and microscopy techniques. Eighty-eight P. nathusii bat carcasses were tested for PN-bCoV RNA by RT-qPCR, of which 25 bats (28%) tested positive. PN-bCoV RNA was more often detected in samples of the intestinal tract than in other sample types. In addition, viral RNA loads were higher in intestinal samples compared to other sample types, both on average and in each individual bat. In one bat, we demonstrated Merbecovirus antigen and PN-bCoV RNA expression in intestinal epithelium and the underlying connective tissue using immunohistochemistry ... Article in Journal/Newspaper Pipistrellus nathusii DataCite |
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Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
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Biodiversity Mammalia Chiroptera Chordata Animalia bats bat Mols, Ara Lamers, Mart M. Leijten, Lonneke Me. Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
topic_facet |
Biodiversity Mammalia Chiroptera Chordata Animalia bats bat |
description |
(Uploaded by Plazi for the Bat Literature Project) The emergence of several bat coronavirus-related disease outbreaks in human and domestic animals has fueled surveillance of coronaviruses in bats worldwide. However, little is known about how these viruses interact with their natural hosts. We demonstrate a Betacoronavirus (subgenus Merbecovirus), PN-bCoV, in the intestine of its natural host, Nathusius's Pipistrelle Bat (Pipistrellus nathusii), by combining molecular and microscopy techniques. Eighty-eight P. nathusii bat carcasses were tested for PN-bCoV RNA by RT-qPCR, of which 25 bats (28%) tested positive. PN-bCoV RNA was more often detected in samples of the intestinal tract than in other sample types. In addition, viral RNA loads were higher in intestinal samples compared to other sample types, both on average and in each individual bat. In one bat, we demonstrated Merbecovirus antigen and PN-bCoV RNA expression in intestinal epithelium and the underlying connective tissue using immunohistochemistry ... |
format |
Article in Journal/Newspaper |
author |
Mols, Ara Lamers, Mart M. Leijten, Lonneke Me. |
author_facet |
Mols, Ara Lamers, Mart M. Leijten, Lonneke Me. |
author_sort |
Mols, Ara |
title |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_short |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_full |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_fullStr |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_full_unstemmed |
Intestinal Tropism of a Betacoronavirus (Merbecovirus)in Nathusius's Pipistrelle Bat (Pipistrellus nathusii), Its Natural Host ... |
title_sort |
intestinal tropism of a betacoronavirus (merbecovirus)in nathusius's pipistrelle bat (pipistrellus nathusii), its natural host ... |
publisher |
Zenodo |
publishDate |
2023 |
url |
https://dx.doi.org/10.5281/zenodo.13439961 https://zenodo.org/doi/10.5281/zenodo.13439961 |
genre |
Pipistrellus nathusii |
genre_facet |
Pipistrellus nathusii |
op_relation |
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op_doi |
https://doi.org/10.5281/zenodo.1343996110.5281/zenodo.141054310.5281/zenodo.13439962 |
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1810472067570597888 |