Integrated Graph-Based Models Unveil Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases. ...

• Main Authors: Ray, Rajarshi, Bhowmik, Ratul, Manaithiya, Ajay, Singh Shyamal, Sagar, Aspatwar, Ashok
• Format: Article in Journal/Newspaper
• Language: English
• Published: Zenodo 2024
• Subjects: Carbonic acid
• Online Access: https://dx.doi.org/10.5281/zenodo.12796528; https://zenodo.org/doi/10.5281/zenodo.12796528

The following repository consists of Python scripts and datasets associated with the overall work related to the manuscript: Integrated Graph-Based Models Unveil Carbonic Anhydrase VIII, X, XI Expression in Cancer and Neurological Diseases. Carbonic anhydrases (CA) belong to the class of metalloenzymes that are known to exist among living organisms and are known for their catalytic activity in reversible reactions between carbon dioxide and water, leading to the exchange of carbonic acid constituents within the various cells and tissues of living organisms, specifically within human beings. Hence, CAs are responsible for maintaining overall balance along the respiratory and renal processes, maintaining acid-base balance, and regulating pH within the tissues and organs, respectively. While most of the CAs found within vertebrates are known to be active enzymes due to the presence of a zinc active site, a family of CAs known as CA-related proteins (CARPs) constitute the CA VIII, X, and XI (8, 10, and 11), ...