Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ...
Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations...
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ftdatacite:10.5061/dryad.vk4br80 2024-06-09T07:39:13+00:00 Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan 2019 https://dx.doi.org/10.5061/dryad.vk4br80 https://datadryad.org/stash/dataset/doi:10.5061/dryad.vk4br80 en eng Dryad https://dx.doi.org/10.1002/ece3.5317 Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 Antarctic fur seal heterozygosity fitness correlation HFC Inbreeding Arctocephalus gazella Bacterial infection Dataset dataset 2019 ftdatacite https://doi.org/10.5061/dryad.vk4br8010.1002/ece3.5317 2024-05-13T11:06:59Z Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations have been widely reported at both neutral and functional loci, yet few studies have directly compared the two, making it difficult to gauge the relative contributions of genome-wide inbreeding and functional genetic variation to fitness. Here, we compared the effects of neutral and immune gene heterozygosity on death from bacterial infection in Antarctic fur seal (Arctocephalus gazella) pups. We specifically developed a panel of 13 microsatellites from expressed immune genes and genotyped these together with 48 neutral loci in 234 individuals, comprising 39 pups that were classified at necropsy as having most likely died of bacterial infection together with a five times larger matched sample of healthy surviving ... : Supplementary Table S12362 microsatellite loci identified from the Antarctic fur seal transcriptome assembly that consist of a minimum of five short tandem repeats with perfect di-, tri- and tetranucleotide motifs.Supplementary Table S296 microsatellite loci selected for testing, comprising twenty that appeared polymorphic in silico as described by Hoffman and Nichols (2011) plus a further 76 loci that carried at least six repeat units.Supplementary Table S3Summary of the eleven immune microsatellites developed as part of this study.Supplementary Table S4Summary of the 48 neutral loci and the two previously published immune loci (Hoffman and Nichols, 2011) genotyped in this study, including their polymorphism characteristics in 234 Antarctic fur seal individuals.Supplementary File S1R-Markdown CodeSupplementary File S1R-Markdown PDFImmuneMicrosats_supplementaryarc_gaz_transcriptome.fastaarc_gaz_transcriptome.fastaarc_gaz_transcriptome_annotationsimmune_microsats_rawp3_in_fur_sealpvaluesTable of p-values for ... Dataset Antarc* Antarctic Antarctic Fur Seal Antarctic Fur Seals Arctocephalus gazella DataCite Metadata Store (German National Library of Science and Technology) Antarctic The Antarctic |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
Antarctic fur seal heterozygosity fitness correlation HFC Inbreeding Arctocephalus gazella Bacterial infection |
spellingShingle |
Antarctic fur seal heterozygosity fitness correlation HFC Inbreeding Arctocephalus gazella Bacterial infection Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... |
topic_facet |
Antarctic fur seal heterozygosity fitness correlation HFC Inbreeding Arctocephalus gazella Bacterial infection |
description |
Numerous studies have reported correlations between the heterozygosity of genetic markers and fitness. These heterozygosity fitness correlations (HFCs) play a central role in evolutionary and conservation biology, yet their mechanistic basis remains open to debate. For example, fitness associations have been widely reported at both neutral and functional loci, yet few studies have directly compared the two, making it difficult to gauge the relative contributions of genome-wide inbreeding and functional genetic variation to fitness. Here, we compared the effects of neutral and immune gene heterozygosity on death from bacterial infection in Antarctic fur seal (Arctocephalus gazella) pups. We specifically developed a panel of 13 microsatellites from expressed immune genes and genotyped these together with 48 neutral loci in 234 individuals, comprising 39 pups that were classified at necropsy as having most likely died of bacterial infection together with a five times larger matched sample of healthy surviving ... : Supplementary Table S12362 microsatellite loci identified from the Antarctic fur seal transcriptome assembly that consist of a minimum of five short tandem repeats with perfect di-, tri- and tetranucleotide motifs.Supplementary Table S296 microsatellite loci selected for testing, comprising twenty that appeared polymorphic in silico as described by Hoffman and Nichols (2011) plus a further 76 loci that carried at least six repeat units.Supplementary Table S3Summary of the eleven immune microsatellites developed as part of this study.Supplementary Table S4Summary of the 48 neutral loci and the two previously published immune loci (Hoffman and Nichols, 2011) genotyped in this study, including their polymorphism characteristics in 234 Antarctic fur seal individuals.Supplementary File S1R-Markdown CodeSupplementary File S1R-Markdown PDFImmuneMicrosats_supplementaryarc_gaz_transcriptome.fastaarc_gaz_transcriptome.fastaarc_gaz_transcriptome_annotationsimmune_microsats_rawp3_in_fur_sealpvaluesTable of p-values for ... |
format |
Dataset |
author |
Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan |
author_facet |
Litzke, Vivienne Ottensmann, Meinolf Forcada, Jaume Heitzmann, Louise Hoffman, Joseph Ivan |
author_sort |
Litzke, Vivienne |
title |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... |
title_short |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... |
title_full |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... |
title_fullStr |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... |
title_full_unstemmed |
Data from: Heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in Antarctic fur seals ... |
title_sort |
data from: heterozygosity at neutral and immune loci is not associated with neonatal mortality due to microbial infection in antarctic fur seals ... |
publisher |
Dryad |
publishDate |
2019 |
url |
https://dx.doi.org/10.5061/dryad.vk4br80 https://datadryad.org/stash/dataset/doi:10.5061/dryad.vk4br80 |
geographic |
Antarctic The Antarctic |
geographic_facet |
Antarctic The Antarctic |
genre |
Antarc* Antarctic Antarctic Fur Seal Antarctic Fur Seals Arctocephalus gazella |
genre_facet |
Antarc* Antarctic Antarctic Fur Seal Antarctic Fur Seals Arctocephalus gazella |
op_relation |
https://dx.doi.org/10.1002/ece3.5317 |
op_rights |
Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 |
op_doi |
https://doi.org/10.5061/dryad.vk4br8010.1002/ece3.5317 |
_version_ |
1801378060848594944 |