R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ...
Structural variations (SVs) represent a large fraction of all genetic diversity, but how this genetic diversity is translated into phenotypic and organismal diversity is unclear. Explosive diversification of dog coat color and patterns after domestication can provide a unique opportunity to explore...
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Online Access: | https://dx.doi.org/10.5061/dryad.qz612jmdt https://datadryad.org/stash/dataset/doi:10.5061/dryad.qz612jmdt |
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ftdatacite:10.5061/dryad.qz612jmdt 2024-10-13T14:06:33+00:00 R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... Kawakami, Takeshi Jensen, Meghan Slavney, Andrea Milano, Ausra Raghavan, Vandana Ford, Brett Sams, Aaron Boyko, Adam 2021 https://dx.doi.org/10.5061/dryad.qz612jmdt https://datadryad.org/stash/dataset/doi:10.5061/dryad.qz612jmdt en eng Dryad Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 pigmentation coat color structural variation Canis lupus familiaris SNP array genotyping Dataset dataset 2021 ftdatacite https://doi.org/10.5061/dryad.qz612jmdt 2024-10-01T11:12:04Z Structural variations (SVs) represent a large fraction of all genetic diversity, but how this genetic diversity is translated into phenotypic and organismal diversity is unclear. Explosive diversification of dog coat color and patterns after domestication can provide a unique opportunity to explore this question; however, the major obstacle is to efficiently collect a sufficient number of individuals with known phenotypes and genotypes of hundreds of thousands of markers. Using customer-provided information about coat color and patterns of dogs tested on a commercial canine genotyping platform, we identified a genomic region on chromosome 38 that is strongly associated with a mottled coat pattern (roaning) by genome-wide association study. We identified a putative causal variant in this region, an 11-kb tandem duplication (11,131,835-11,143,237) characterized by sequence read coverage and discordant reads of whole-genome sequence data, microarray probe intensity data, and a duplication-specific PCR assay. ... : DNA was extracted from buccal swab samples collected by dog owners and extracted by Illumina, Inc. Genotypes of the dogs were collected by using custom Illumina Canine high-density SNP arrays (a total of 220,484 markers). ... Dataset Canis lupus DataCite |
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collection |
DataCite |
op_collection_id |
ftdatacite |
language |
English |
topic |
pigmentation coat color structural variation Canis lupus familiaris SNP array genotyping |
spellingShingle |
pigmentation coat color structural variation Canis lupus familiaris SNP array genotyping Kawakami, Takeshi Jensen, Meghan Slavney, Andrea Milano, Ausra Raghavan, Vandana Ford, Brett Sams, Aaron Boyko, Adam R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... |
topic_facet |
pigmentation coat color structural variation Canis lupus familiaris SNP array genotyping |
description |
Structural variations (SVs) represent a large fraction of all genetic diversity, but how this genetic diversity is translated into phenotypic and organismal diversity is unclear. Explosive diversification of dog coat color and patterns after domestication can provide a unique opportunity to explore this question; however, the major obstacle is to efficiently collect a sufficient number of individuals with known phenotypes and genotypes of hundreds of thousands of markers. Using customer-provided information about coat color and patterns of dogs tested on a commercial canine genotyping platform, we identified a genomic region on chromosome 38 that is strongly associated with a mottled coat pattern (roaning) by genome-wide association study. We identified a putative causal variant in this region, an 11-kb tandem duplication (11,131,835-11,143,237) characterized by sequence read coverage and discordant reads of whole-genome sequence data, microarray probe intensity data, and a duplication-specific PCR assay. ... : DNA was extracted from buccal swab samples collected by dog owners and extracted by Illumina, Inc. Genotypes of the dogs were collected by using custom Illumina Canine high-density SNP arrays (a total of 220,484 markers). ... |
format |
Dataset |
author |
Kawakami, Takeshi Jensen, Meghan Slavney, Andrea Milano, Ausra Raghavan, Vandana Ford, Brett Sams, Aaron Boyko, Adam |
author_facet |
Kawakami, Takeshi Jensen, Meghan Slavney, Andrea Milano, Ausra Raghavan, Vandana Ford, Brett Sams, Aaron Boyko, Adam |
author_sort |
Kawakami, Takeshi |
title |
R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... |
title_short |
R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... |
title_full |
R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... |
title_fullStr |
R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... |
title_full_unstemmed |
R-locus for roaned coat is associated with a tandem duplication in an intronic region of USH2A in dogs and also contributes to Dalmatian spotting ... |
title_sort |
r-locus for roaned coat is associated with a tandem duplication in an intronic region of ush2a in dogs and also contributes to dalmatian spotting ... |
publisher |
Dryad |
publishDate |
2021 |
url |
https://dx.doi.org/10.5061/dryad.qz612jmdt https://datadryad.org/stash/dataset/doi:10.5061/dryad.qz612jmdt |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_rights |
Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 |
op_doi |
https://doi.org/10.5061/dryad.qz612jmdt |
_version_ |
1812812746143563776 |