Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ...
Population bottlenecks, inbreeding, and artificial selection can all, in principle, influence levels of deleterious genetic variation. However, the relative importance of each of these effects on genome-wide patterns of deleterious variation remains controversial. Domestic and wild canids offer a po...
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ftdatacite:10.5061/dryad.012s5 2024-10-13T14:06:32+00:00 Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... Marsden, Clare D. Ortega-Del Vecchyo, Diego O'Brien, Dennis P. Taylor, Jeremy F. Ramirez, Oscar Vila, Carles Marques-Bonet, Tomas Schnabel, Robert D. Wayne, Robert K. Lohmueller, Kirk E. 2016 https://dx.doi.org/10.5061/dryad.012s5 https://datadryad.org/stash/dataset/doi:10.5061/dryad.012s5 en eng Dryad https://dx.doi.org/10.1073/pnas.1512501113 Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 selective sweep deleterious mutations Canis familiaris Canis lupus Dataset dataset 2016 ftdatacite https://doi.org/10.5061/dryad.012s510.1073/pnas.1512501113 2024-10-01T11:09:16Z Population bottlenecks, inbreeding, and artificial selection can all, in principle, influence levels of deleterious genetic variation. However, the relative importance of each of these effects on genome-wide patterns of deleterious variation remains controversial. Domestic and wild canids offer a powerful system to address the role of these factors in influencing deleterious variation because their history is dominated by known bottlenecks and intense artificial selection. Here, we assess genome-wide patterns of deleterious variation in 90 whole-genome sequences from breed dogs, village dogs, and gray wolves. We find that the ratio of amino acid changing heterozygosity to silent heterozygosity is higher in dogs than in wolves and, on average, dogs have 2–3% higher genetic load than gray wolves. Multiple lines of evidence indicate this pattern is driven by less efficient natural selection due to bottlenecks associated with domestication and breed formation, rather than recent inbreeding. Further, we find ... : DOG_jackknife_on_sweep_nonsweep_dataWOLF_jackknife_on_sweep_nonsweep_dataDogwolf_vcf_Filtered_coding_region_with_Miyata_and_GerpScore_annotated.vcfGene_IDs_overlapping_sweep_regions.final ... Dataset Canis lupus DataCite |
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ftdatacite |
language |
English |
topic |
selective sweep deleterious mutations Canis familiaris Canis lupus |
spellingShingle |
selective sweep deleterious mutations Canis familiaris Canis lupus Marsden, Clare D. Ortega-Del Vecchyo, Diego O'Brien, Dennis P. Taylor, Jeremy F. Ramirez, Oscar Vila, Carles Marques-Bonet, Tomas Schnabel, Robert D. Wayne, Robert K. Lohmueller, Kirk E. Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
topic_facet |
selective sweep deleterious mutations Canis familiaris Canis lupus |
description |
Population bottlenecks, inbreeding, and artificial selection can all, in principle, influence levels of deleterious genetic variation. However, the relative importance of each of these effects on genome-wide patterns of deleterious variation remains controversial. Domestic and wild canids offer a powerful system to address the role of these factors in influencing deleterious variation because their history is dominated by known bottlenecks and intense artificial selection. Here, we assess genome-wide patterns of deleterious variation in 90 whole-genome sequences from breed dogs, village dogs, and gray wolves. We find that the ratio of amino acid changing heterozygosity to silent heterozygosity is higher in dogs than in wolves and, on average, dogs have 2–3% higher genetic load than gray wolves. Multiple lines of evidence indicate this pattern is driven by less efficient natural selection due to bottlenecks associated with domestication and breed formation, rather than recent inbreeding. Further, we find ... : DOG_jackknife_on_sweep_nonsweep_dataWOLF_jackknife_on_sweep_nonsweep_dataDogwolf_vcf_Filtered_coding_region_with_Miyata_and_GerpScore_annotated.vcfGene_IDs_overlapping_sweep_regions.final ... |
format |
Dataset |
author |
Marsden, Clare D. Ortega-Del Vecchyo, Diego O'Brien, Dennis P. Taylor, Jeremy F. Ramirez, Oscar Vila, Carles Marques-Bonet, Tomas Schnabel, Robert D. Wayne, Robert K. Lohmueller, Kirk E. |
author_facet |
Marsden, Clare D. Ortega-Del Vecchyo, Diego O'Brien, Dennis P. Taylor, Jeremy F. Ramirez, Oscar Vila, Carles Marques-Bonet, Tomas Schnabel, Robert D. Wayne, Robert K. Lohmueller, Kirk E. |
author_sort |
Marsden, Clare D. |
title |
Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
title_short |
Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
title_full |
Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
title_fullStr |
Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
title_full_unstemmed |
Data from: Bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
title_sort |
data from: bottlenecks and selective sweeps during domestication have increased deleterious genetic variation in dogs ... |
publisher |
Dryad |
publishDate |
2016 |
url |
https://dx.doi.org/10.5061/dryad.012s5 https://datadryad.org/stash/dataset/doi:10.5061/dryad.012s5 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
https://dx.doi.org/10.1073/pnas.1512501113 |
op_rights |
Creative Commons Zero v1.0 Universal https://creativecommons.org/publicdomain/zero/1.0/legalcode cc0-1.0 |
op_doi |
https://doi.org/10.5061/dryad.012s510.1073/pnas.1512501113 |
_version_ |
1812812734065016832 |