Genetic recombination is targeted towards gene promoter regions in dogs
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version of PR...
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ftdatacite:10.48550/arxiv.1305.6485 2023-05-15T15:50:26+02:00 Genetic recombination is targeted towards gene promoter regions in dogs Auton, Adam Li, Ying Rui Kidd, Jeffrey Oliveira, Kyle Nadel, Julie Holloway, J. Kim Hayward, Jessica J. Cohen, Paula E. Greally, John M. Wang, Jun Bustamante, Carlos D. Boyko, Adam R. 2013 https://dx.doi.org/10.48550/arxiv.1305.6485 https://arxiv.org/abs/1305.6485 unknown arXiv https://dx.doi.org/10.1371/journal.pgen.1003984 arXiv.org perpetual, non-exclusive license http://arxiv.org/licenses/nonexclusive-distrib/1.0/ Populations and Evolution q-bio.PE Genomics q-bio.GN FOS Biological sciences article-journal Article ScholarlyArticle Text 2013 ftdatacite https://doi.org/10.48550/arxiv.1305.6485 https://doi.org/10.1371/journal.pgen.1003984 2022-04-01T13:38:24Z The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version of PRDM9 and may therefore provide a model for understanding recombination that occurs in the absence of PRDM9, and thus how PRDM9 functions to shape the recombination landscape. We have constructed a fine-scale genetic map from patterns of linkage disequilibrium assessed using high-throughput sequence data from 51 free-ranging dogs, Canis lupus familiaris. While broad-scale properties of recombination appear similar to other mammalian species, our fine-scale estimates indicate that canine highly elevated recombination rates are observed in the vicinity of CpG rich regions including gene promoter regions, but show little association with H3K4 trimethylation marks identified in spermatocytes. By comparison to genomic data from the Andean fox, Lycalopex culpaeus, we show that biased gene conversion is a plausible mechanism by which the high CpG content of the dog genome could have occurred. : Updated version, with significant revisions Text Canis lupus DataCite Metadata Store (German National Library of Science and Technology) |
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Populations and Evolution q-bio.PE Genomics q-bio.GN FOS Biological sciences |
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Populations and Evolution q-bio.PE Genomics q-bio.GN FOS Biological sciences Auton, Adam Li, Ying Rui Kidd, Jeffrey Oliveira, Kyle Nadel, Julie Holloway, J. Kim Hayward, Jessica J. Cohen, Paula E. Greally, John M. Wang, Jun Bustamante, Carlos D. Boyko, Adam R. Genetic recombination is targeted towards gene promoter regions in dogs |
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Populations and Evolution q-bio.PE Genomics q-bio.GN FOS Biological sciences |
description |
The identification of the H3K4 trimethylase, PRDM9, as the gene responsible for recombination hotspot localization has provided considerable insight into the mechanisms by which recombination is initiated in mammals. However, uniquely amongst mammals, canids appear to lack a functional version of PRDM9 and may therefore provide a model for understanding recombination that occurs in the absence of PRDM9, and thus how PRDM9 functions to shape the recombination landscape. We have constructed a fine-scale genetic map from patterns of linkage disequilibrium assessed using high-throughput sequence data from 51 free-ranging dogs, Canis lupus familiaris. While broad-scale properties of recombination appear similar to other mammalian species, our fine-scale estimates indicate that canine highly elevated recombination rates are observed in the vicinity of CpG rich regions including gene promoter regions, but show little association with H3K4 trimethylation marks identified in spermatocytes. By comparison to genomic data from the Andean fox, Lycalopex culpaeus, we show that biased gene conversion is a plausible mechanism by which the high CpG content of the dog genome could have occurred. : Updated version, with significant revisions |
format |
Text |
author |
Auton, Adam Li, Ying Rui Kidd, Jeffrey Oliveira, Kyle Nadel, Julie Holloway, J. Kim Hayward, Jessica J. Cohen, Paula E. Greally, John M. Wang, Jun Bustamante, Carlos D. Boyko, Adam R. |
author_facet |
Auton, Adam Li, Ying Rui Kidd, Jeffrey Oliveira, Kyle Nadel, Julie Holloway, J. Kim Hayward, Jessica J. Cohen, Paula E. Greally, John M. Wang, Jun Bustamante, Carlos D. Boyko, Adam R. |
author_sort |
Auton, Adam |
title |
Genetic recombination is targeted towards gene promoter regions in dogs |
title_short |
Genetic recombination is targeted towards gene promoter regions in dogs |
title_full |
Genetic recombination is targeted towards gene promoter regions in dogs |
title_fullStr |
Genetic recombination is targeted towards gene promoter regions in dogs |
title_full_unstemmed |
Genetic recombination is targeted towards gene promoter regions in dogs |
title_sort |
genetic recombination is targeted towards gene promoter regions in dogs |
publisher |
arXiv |
publishDate |
2013 |
url |
https://dx.doi.org/10.48550/arxiv.1305.6485 https://arxiv.org/abs/1305.6485 |
genre |
Canis lupus |
genre_facet |
Canis lupus |
op_relation |
https://dx.doi.org/10.1371/journal.pgen.1003984 |
op_rights |
arXiv.org perpetual, non-exclusive license http://arxiv.org/licenses/nonexclusive-distrib/1.0/ |
op_doi |
https://doi.org/10.48550/arxiv.1305.6485 https://doi.org/10.1371/journal.pgen.1003984 |
_version_ |
1766385367544496128 |