Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ...
PCOS confers an increased risk for obesity-related comorbidities. It has been challenging to identify precise risk genes associated with the pathogenesis of PCOS. A novel variant located within MYO10 intron 2 (rs9312937) was identified in a PCOS GWAS in the genetically isolated Finnish and related E...
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Online Access: | https://dx.doi.org/10.48448/zyvk-h954 https://underline.io/lecture/63647-risk-variants-at-the-myo10-locus-are-associated-with-metabolic-traits |
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ftdatacite:10.48448/zyvk-h954 2023-06-11T04:13:03+02:00 Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... Endocrine Society 2022 Battiola, Tess 2022 https://dx.doi.org/10.48448/zyvk-h954 https://underline.io/lecture/63647-risk-variants-at-the-myo10-locus-are-associated-with-metabolic-traits unknown Underline Science Inc. Endocrinology Audiovisual MediaObject Conference talk article 2022 ftdatacite https://doi.org/10.48448/zyvk-h954 2023-06-01T11:24:26Z PCOS confers an increased risk for obesity-related comorbidities. It has been challenging to identify precise risk genes associated with the pathogenesis of PCOS. A novel variant located within MYO10 intron 2 (rs9312937) was identified in a PCOS GWAS in the genetically isolated Finnish and related Estonian populations. We identified PCOS risk variants at the MYO10 locus in additional PCOS populations. We hypothesized that PCOS risk variants at the locus were associated with metabolic traits. Women from Iceland (n=1347) and Boston (n=591) were diagnosed with PCOS using the Rotterdam criteria and NIH criteria, respectively, with a non-overlapping replication cohort (n=586) identified using an algorithm incorporating ICD codes and natural language processing. Controls included population controls from Iceland (effective n=1200), well-phenotyped controls from Boston (n=441) and a cohort with no PCOS diagnoses or features in the electronic medical record (EMR; n=749). We performed an association study to identify ... Article in Journal/Newspaper Iceland DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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Endocrinology |
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Endocrinology Endocrine Society 2022 Battiola, Tess Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... |
topic_facet |
Endocrinology |
description |
PCOS confers an increased risk for obesity-related comorbidities. It has been challenging to identify precise risk genes associated with the pathogenesis of PCOS. A novel variant located within MYO10 intron 2 (rs9312937) was identified in a PCOS GWAS in the genetically isolated Finnish and related Estonian populations. We identified PCOS risk variants at the MYO10 locus in additional PCOS populations. We hypothesized that PCOS risk variants at the locus were associated with metabolic traits. Women from Iceland (n=1347) and Boston (n=591) were diagnosed with PCOS using the Rotterdam criteria and NIH criteria, respectively, with a non-overlapping replication cohort (n=586) identified using an algorithm incorporating ICD codes and natural language processing. Controls included population controls from Iceland (effective n=1200), well-phenotyped controls from Boston (n=441) and a cohort with no PCOS diagnoses or features in the electronic medical record (EMR; n=749). We performed an association study to identify ... |
format |
Article in Journal/Newspaper |
author |
Endocrine Society 2022 Battiola, Tess |
author_facet |
Endocrine Society 2022 Battiola, Tess |
author_sort |
Endocrine Society 2022 |
title |
Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... |
title_short |
Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... |
title_full |
Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... |
title_fullStr |
Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... |
title_full_unstemmed |
Risk Variants at the MYO10 Locus are Associated with Metabolic Traits ... |
title_sort |
risk variants at the myo10 locus are associated with metabolic traits ... |
publisher |
Underline Science Inc. |
publishDate |
2022 |
url |
https://dx.doi.org/10.48448/zyvk-h954 https://underline.io/lecture/63647-risk-variants-at-the-myo10-locus-are-associated-with-metabolic-traits |
genre |
Iceland |
genre_facet |
Iceland |
op_doi |
https://doi.org/10.48448/zyvk-h954 |
_version_ |
1768389631738380288 |