Gene co-expression patterns in Atlantic salmon adipose tissue provide a molecular link among seasonal changes, energy balance and age at maturity. ...

• Main Authors: Ahi, Ehsan Pashay, Verta, Jukka-Pekka, Kurko, Johanna, Ruokolainen, Annukka, Singh, Pooja, Debes, Paul Vincent, Erkinaro, Jaakko, Primmer, Craig R
• Format: Text
• Language: unknown
• Published: Wiley-Blackwell 2024
• Subjects: 570 Biowissenschaften; Biologie; Atlantic salmon
• Online Access: https://dx.doi.org/10.48350/193734; https://boris.unibe.ch/193734/

Sexual maturation in many fishes requires a major physiological change that involves a rapid transition between energy storage and usage. In Atlantic salmon, this transition for the initiation of maturation is tightly controlled by seasonality and requires a high-energy status. Lipid metabolism is at the heart of this transition since lipids are the main energy storing molecules. The balance between lipogenesis (lipid accumulation) and lipolysis (lipid use) determines energy status transitions. A genomic region containing a transcription co-factor of the Hippo pathway, vgll3, is the main determinant of maturation timing in Atlantic salmon. Interestingly, vgll3 acts as an inhibitor of adipogenesis in mice and its genotypes are potentially associated with seasonal heterochrony in lipid storage and usage in juvenile Atlantic salmon. Here, we explored changes in expression of more than 300 genes directly involved in the processes of adipogenesis, lipogenesis and lipolysis, as well as the Hippo pathway in the ...