Hantavirus–Leptospira coinfections in small mammals from central Germany
European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the...
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Cambridge University Press
2021
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ftdatacite:10.48350/164208 2023-05-15T17:12:34+02:00 Hantavirus–Leptospira coinfections in small mammals from central Germany Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. 2021 https://dx.doi.org/10.48350/164208 https://boris.unibe.ch/164208/ unknown Cambridge University Press https://dx.doi.org/10.1017/S0950268821000443 open access Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 http://purl.org/coar/access_right/c_abf2 CC-BY 570 Life sciences; biology article-journal journal article ScholarlyArticle Text 2021 ftdatacite https://doi.org/10.48350/164208 https://doi.org/10.1017/S0950268821000443 2022-03-10T10:29:32Z European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (Microtus agrestis) with 54.5% (6/11) and common voles (Microtus arvalis) with 30.3% (205/676). Leptospira–hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. Article in Journal/Newspaper Microtus arvalis DataCite Metadata Store (German National Library of Science and Technology) Tula ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
institution |
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collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
570 Life sciences; biology |
spellingShingle |
570 Life sciences; biology Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. Hantavirus–Leptospira coinfections in small mammals from central Germany |
topic_facet |
570 Life sciences; biology |
description |
European orthohantaviruses (Puumala orthohantavirus (PUUV); Dobrava-Belgrade orthohantavirus (DOBV), genotype Kurkino; Tula orthohantavirus (TULV)), and Leptospira spp. are small mammal-associated zoonotic pathogens that cause diseases with potentially similar symptoms in humans.We investigated the frequency of Leptospira spp. and hantavirus single and double infections in small mammals from 22 sites in Thuringia, central Germany, during 2017. TULV infections were detected at 18 of 22 sites (mean prevalence 13.8%, 93/674). PUUV infections were detected at four of 22 sites (mean prevalence 1.5%, 7/471), and respective PUUV sequences formed a novel phylogenetic clade, but DOBV infections were not detected at all. Leptospira infections were detected at 21 of 22 sites with the highest overall prevalence in field voles (Microtus agrestis) with 54.5% (6/11) and common voles (Microtus arvalis) with 30.3% (205/676). Leptospira–hantavirus coinfections were found in 6.6% (44/671) of common voles but only in two of 395 bank voles. TULV and Leptospira coinfection probability in common voles was driven by individual (age) and population-level factors. Coinfections seemed to be particularly associated with sites where Leptospira spp. prevalence exceeded 35%. Future investigations should evaluate public health consequences of this strong spatial clustering of coinfections. |
format |
Article in Journal/Newspaper |
author |
Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. |
author_facet |
Jeske, K. Jacob, J. Drewes, S. Pfeffer, M. Heckel, G. Ulrich, R. G. Imholt, C. |
author_sort |
Jeske, K. |
title |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_short |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_full |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_fullStr |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_full_unstemmed |
Hantavirus–Leptospira coinfections in small mammals from central Germany |
title_sort |
hantavirus–leptospira coinfections in small mammals from central germany |
publisher |
Cambridge University Press |
publishDate |
2021 |
url |
https://dx.doi.org/10.48350/164208 https://boris.unibe.ch/164208/ |
long_lat |
ENVELOPE(-65.650,-65.650,-65.517,-65.517) |
geographic |
Tula |
geographic_facet |
Tula |
genre |
Microtus arvalis |
genre_facet |
Microtus arvalis |
op_relation |
https://dx.doi.org/10.1017/S0950268821000443 |
op_rights |
open access Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 http://purl.org/coar/access_right/c_abf2 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.48350/164208 https://doi.org/10.1017/S0950268821000443 |
_version_ |
1766069361752145920 |