Living with arrhythmogenic right ventricular cardiomyopathy caused by a p.S358L disease-causing variant in TMEM43: symptoms of anxiety, depression, and posttraumatic stress in non-carrier first-degree relatives of patients with an ICD ...
This pilot study investigated the mental health impact of implantable cardioverter defibrillator (ICD) therapy on families in Newfoundland and Labrador that are affected by arrhythmogenic right ventricular cardiomyopathy caused by a p.S358L mutation in transmembrane protein 43 (TMEM43). The sample f...
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| Format: | Text |
| Language: | English |
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Memorial University of Newfoundland
2020
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| Online Access: | https://dx.doi.org/10.48336/rr12-9v50 https://research.library.mun.ca/15671/ |
| Summary: | This pilot study investigated the mental health impact of implantable cardioverter defibrillator (ICD) therapy on families in Newfoundland and Labrador that are affected by arrhythmogenic right ventricular cardiomyopathy caused by a p.S358L mutation in transmembrane protein 43 (TMEM43). The sample for this study was individuals born at an a priori 50% risk of having the TMEM43 mutation but tested negative and had a first-degree relative with an ICD. A total of 25 participants completed three psychometric scales that assessed symptoms of depression, anxiety, and post-traumatic stress disorder (PTSD). Our sample scored significantly lower on depression, anxiety, and PTSD than ICD patients but significantly higher on anxiety than the general population. A significant relationship was observed between symptoms of anxiety and the duration of time since their relative had an ICD implanted. As the time since implant increased, anxiety significantly decreased. These preliminary findings suggest that testing negative ... |
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