Renibacterium salmoninarum and Aeromonas salmonicida pathogenesis and virulence in lumpfish (Cyclopterus lumpus) ...

• Main Author: Gnanagobal, Hajarooba
• Format: Text
• Language: English
• Published: Memorial University of Newfoundland 2023
• Subjects: Atlantic salmon; Salmo salar
• Online Access: https://dx.doi.org/10.48336/azmc-rr46; https://research.library.mun.ca/16133/

Renibacterium salmoninarum, the etiological agent of Bacterial Kidney Disease (BKD), and Aeromonas salmonicida, which causes furunculosis, are economically important pathogens of marine fish. The marine teleost lumpfish (Cyclopterus lumpus) is an eco-friendly cleaner fish in Atlantic salmon (Salmo salar) farming. As the lumpfish demand in salmonid aquaculture continues to rise, understanding how lumpfish interact with well-known Gram-positive and Gram-negative fish pathogens is certainly required. Therefore, in my Ph.D. thesis, I studied the interactions between lumpfish host and Grampositive R. salmoninarum or Gram-negative A. salmonicida with a particular focus on the fundamental aspects of bacterial pathogenicity and virulence. First, I evaluated the lumpfish susceptibility and immune response to R. salmoninarum infection. Lumpfish showed typical BKD clinical signs and 35 % mortality when infected with a high dose of R. salmoninarum (1×109 cells dose-1). High bacterial loads were observed in tissues ...