Ancient human genome sequence of an extinct Palaeo-Eskimo
We report here the genome sequence of an ancient human. Obtained from ~4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to...
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Online Ancient Genome Repository
2010
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Online Access: | https://dx.doi.org/10.4225/55/57819b1867475 https://www.oagr.org.au/experiment/view/43/ |
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ftdatacite:10.4225/55/57819b1867475 2023-05-15T16:07:28+02:00 Ancient human genome sequence of an extinct Palaeo-Eskimo Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M Thomas P Wang, Yong Raghavan, Maanasa Campos, Paula F Munkholm Kamp, Hanne Wilson, Andrew S Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A Osipova, Ludmila P Higham, Thomas FG Bronk Ramsey, Christopher V. O. Hansen, Thomas Nielsen, Finn C Crawford, Michael H Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske 2010 https://dx.doi.org/10.4225/55/57819b1867475 https://www.oagr.org.au/experiment/view/43/ unknown Online Ancient Genome Repository Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0 CC-BY Collection article 2010 ftdatacite https://doi.org/10.4225/55/57819b1867475 2021-11-05T12:55:41Z We report here the genome sequence of an ancient human. Obtained from ~4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. Article in Journal/Newspaper eskimo* Greenland inuit permafrost Siberia DataCite Metadata Store (German National Library of Science and Technology) Greenland |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
description |
We report here the genome sequence of an ancient human. Obtained from ~4,000-year-old permafrost-preserved hair, the genome represents a male individual from the first known culture to settle in Greenland. Sequenced to an average depth of 20×, we recover 79% of the diploid genome, an amount close to the practical limit of current sequencing technologies. We identify 353,151 high-confidence single-nucleotide polymorphisms (SNPs), of which 6.8% have not been reported previously. We estimate raw read contamination to be no higher than 0.8%. We use functional SNP assessment to assign possible phenotypic characteristics of the individual that belonged to a culture whose location has yielded only trace human remains. We compare the high-confidence SNPs to those of contemporary populations to find the populations most closely related to the individual. This provides evidence for a migration from Siberia into the New World some 5,500 years ago, independent of that giving rise to the modern Native Americans and Inuit. |
format |
Article in Journal/Newspaper |
author |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M Thomas P Wang, Yong Raghavan, Maanasa Campos, Paula F Munkholm Kamp, Hanne Wilson, Andrew S Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A Osipova, Ludmila P Higham, Thomas FG Bronk Ramsey, Christopher V. O. Hansen, Thomas Nielsen, Finn C Crawford, Michael H Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske |
spellingShingle |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M Thomas P Wang, Yong Raghavan, Maanasa Campos, Paula F Munkholm Kamp, Hanne Wilson, Andrew S Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A Osipova, Ludmila P Higham, Thomas FG Bronk Ramsey, Christopher V. O. Hansen, Thomas Nielsen, Finn C Crawford, Michael H Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske Ancient human genome sequence of an extinct Palaeo-Eskimo |
author_facet |
Rasmussen, Morten Li, Yingrui Lindgreen, Stinus Pedersen, Jakob Skou Albrechtsen, Anders Moltke, Ida Metspalu, Mait Metspalu, Ene Kivisild, Toomas Gupta, Ramneek Bertalan, Marcelo Nielsen, Kasper Gilbert, M Thomas P Wang, Yong Raghavan, Maanasa Campos, Paula F Munkholm Kamp, Hanne Wilson, Andrew S Gledhill, Andrew Tridico, Silvana Bunce, Michael Lorenzen, Eline D Binladen, Jonas Guo, Xiaosen Zhao, Jing Zhang, Xiuqing Zhang, Hao Li, Zhuo Chen, Minfeng Orlando, Ludovic Kristiansen, Karsten Bak, Mads Tommerup, Niels Bendixen, Christian Pierre, Tracey L Grønnow, Bjarne Meldgaard, Morten Andreasen, Claus Fedorova, Sardana A Osipova, Ludmila P Higham, Thomas FG Bronk Ramsey, Christopher V. O. Hansen, Thomas Nielsen, Finn C Crawford, Michael H Brunak, Søren Sicheritz-Pontén, Thomas Villems, Richard Nielsen, Rasmus Krogh, Anders Wang, Jun Willerslev, Eske |
author_sort |
Rasmussen, Morten |
title |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_short |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_fullStr |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_full_unstemmed |
Ancient human genome sequence of an extinct Palaeo-Eskimo |
title_sort |
ancient human genome sequence of an extinct palaeo-eskimo |
publisher |
Online Ancient Genome Repository |
publishDate |
2010 |
url |
https://dx.doi.org/10.4225/55/57819b1867475 https://www.oagr.org.au/experiment/view/43/ |
geographic |
Greenland |
geographic_facet |
Greenland |
genre |
eskimo* Greenland inuit permafrost Siberia |
genre_facet |
eskimo* Greenland inuit permafrost Siberia |
op_rights |
Creative Commons Attribution 4.0 International (CC BY 4.0) http://creativecommons.org/licenses/by/4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.4225/55/57819b1867475 |
_version_ |
1766403581778329600 |