Controversies in omega-3 efficacy and novel concepts for application ...

• Main Authors: Radcliffe, Jessica, Thomas, Jency, Bramley, Andrea, Kouris-Blazos, Antigone, Radford, Bridget, Scholey, AB, Pipingas, A, Thomas, Colleen, Itsiopoulos, Catherine
• Format: Text
• Language: unknown
• Published: La Trobe 2023
• Subjects: Biomedical and clinical sciences; Medical biochemistry and metabolomics; Nutrition and dietetics; Greenland; inuits
• Online Access: https://dx.doi.org/10.26181/22357684.v1; https://opal.latrobe.edu.au/articles/journal_contribution/Controversies_in_omega-3_efficacy_and_novel_concepts_for_application/22357684/1

Abstract: Interest in the cardioprotective effects of long chain omega-3 polyunsaturated fatty acids (LCn3) was largely influenced by the low rates of cardiovascular disease (CVD) amongst the Inuits of Greenland who consumed a high marine fat diet rich in LCn3s. This finding stimulated years of epidemiological and clinical studies investigating the cardioprotective effects of LCn3s, thought to be primarily mediated through anti-inflammatory (and anti-aggregatory) prostaglandins that protect the vascular wall from pro-inflammatory effects of metabolic stress precipitated by poor diet and lifestyle. Although the original hypothesis of the link between LCn3s and CVD protection was based on a high LCn3 containing diet (namely a high marine fat diet) the majority of clinical trials since have focussed on EPA and DHA supplementation, and results of repeated meta-analyses have not shown conclusive evidence in support of their beneficial health effects. In this review we focus on the controversies that surround the ...