Influenza A virus vaccines and inhibitors

• Main Authors: Arnold, Edward C., Krug, Robert M., Twu, Karen Y., Montelione, Gaetano T., Das, Kalyan Kumar, Ma, Li-Chung, Xiao, Rong, Rei-Lin Kuo
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: United States Patent and Trademark Office 2015
• Subjects: A61B50/39; A61K38/162; A61K39/145; A61K2039/5254; A61K2039/53; C07K14/005; C07K14/47; C12N7/00; C12N2760/16034; C12N2760/16071; C12N2760/16122; C12N2760/16134; C12N2760/16162; No longer published; Avian flu
• Online Access: https://dx.doi.org/10.26153/tsw/3760; https://repositories.lib.utexas.edu/handle/2152/76671

The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development.