Influenza A virus vaccines and inhibitors
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for...
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2014
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ftdatacite:10.26153/tsw/3512 2023-05-15T15:34:21+02:00 Influenza A virus vaccines and inhibitors Arnold, Edward C. Krug, Robert M. Twu, Karen Y. Montelione, Gaetano T. Das, Kalyan Kumar Ma, Li-Chung Xiao, Rong Rei-Lin Kuo 2014 https://dx.doi.org/10.26153/tsw/3512 https://repositories.lib.utexas.edu/handle/2152/76423 unknown United States Patent and Trademark Office Open Open A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 CreativeWork article 2014 ftdatacite https://doi.org/10.26153/tsw/3512 2021-11-05T12:55:41Z The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. Article in Journal/Newspaper Avian flu DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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unknown |
topic |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 |
spellingShingle |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 Arnold, Edward C. Krug, Robert M. Twu, Karen Y. Montelione, Gaetano T. Das, Kalyan Kumar Ma, Li-Chung Xiao, Rong Rei-Lin Kuo Influenza A virus vaccines and inhibitors |
topic_facet |
A61B50/39 A61K38/162 A61K39/145 A61K2039/5254 A61K2039/53 C07K14/005 C07K14/47 C12N7/00 C12N2760/16034 C12N2760/16071 C12N2760/16122 C12N2760/16134 C12N2760/16162 435/236 435/5 435/69.1 |
description |
The present invention includes compositions and methods related to the structure and function of the cellular polyadenylation and specificity factor 30 (CPSF 30) binding site on the surface of the influenza A non-structural protein 1 (NS1). Specifically, critical biochemical reagents, conditions for crystallization and NMR analysis, assays, and general processes are described for (i) discovering, designing, and optimizing small molecule inhibitors of influenza A (avian flu) viruses and (ii) creating attenuated influenza virus strains suitable for avian and human flu vaccine development. |
format |
Article in Journal/Newspaper |
author |
Arnold, Edward C. Krug, Robert M. Twu, Karen Y. Montelione, Gaetano T. Das, Kalyan Kumar Ma, Li-Chung Xiao, Rong Rei-Lin Kuo |
author_facet |
Arnold, Edward C. Krug, Robert M. Twu, Karen Y. Montelione, Gaetano T. Das, Kalyan Kumar Ma, Li-Chung Xiao, Rong Rei-Lin Kuo |
author_sort |
Arnold, Edward C. |
title |
Influenza A virus vaccines and inhibitors |
title_short |
Influenza A virus vaccines and inhibitors |
title_full |
Influenza A virus vaccines and inhibitors |
title_fullStr |
Influenza A virus vaccines and inhibitors |
title_full_unstemmed |
Influenza A virus vaccines and inhibitors |
title_sort |
influenza a virus vaccines and inhibitors |
publisher |
United States Patent and Trademark Office |
publishDate |
2014 |
url |
https://dx.doi.org/10.26153/tsw/3512 https://repositories.lib.utexas.edu/handle/2152/76423 |
genre |
Avian flu |
genre_facet |
Avian flu |
op_rights |
Open Open |
op_doi |
https://doi.org/10.26153/tsw/3512 |
_version_ |
1766364774568820736 |