Physeter macrocephalus Transcriptome or Gene expression

Physeter macrocephalus (sperm whale) is being sequenced as an aquatic model organism for the study of respiratory disease, metal toxicity and cancer. Whales are known to accumulate high levels of metals such as chromium, a human lung carcinogen and contributor to other forms of lung disease. Given t...

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Bibliographic Details
Main Author: BGI
Format: Dataset
Language:English
Published: CNGB 2012
Subjects:
Transcriptome or Gene expression
Multiisolate
Physeter macrocephalus
Sperm whale
Online Access:https://dx.doi.org/10.26036/cnphis0001086
https://db.cngb.org/search/project/PRJNA177694/
id ftdatacite:10.26036/cnphis0001086
record_format openpolar
spelling ftdatacite:10.26036/cnphis0001086 2023-05-15T17:59:20+02:00 Physeter macrocephalus Transcriptome or Gene expression BGI 2012 https://dx.doi.org/10.26036/cnphis0001086 https://db.cngb.org/search/project/PRJNA177694/ en eng CNGB Transcriptome or Gene expression Multiisolate dataset Dataset ftp://ftp.cngb.org/pub/sra/sra-instant/reads/ByStudy/sra/SRP/SRP016/SRP016870 2012 ftdatacite https://doi.org/10.26036/cnphis0001086 2021-11-05T12:55:41Z Physeter macrocephalus (sperm whale) is being sequenced as an aquatic model organism for the study of respiratory disease, metal toxicity and cancer. Whales are known to accumulate high levels of metals such as chromium, a human lung carcinogen and contributor to other forms of lung disease. Given that the levels of chromium in whale tissue are sufficient to seriously impair or even kill terrestrial mammals, it is hypothesized that marine mammals have evolved novel repair mechanisms that can protect their DNA from metals like chromium. Hypoxia is a well-known cause of respiratory-related diseases such as sleep apnea, chronic obstructive pulmonary disease and pulmonary emphysema. Marine mammals, however, can dive to great depths for prolonged periods of time and not experience these ill effects of hypoxia. The availability of sperm whale genome resources will allow scientists to investigate the molecular pathways contributing to these adaptations. Dataset Physeter macrocephalus Sperm whale DataCite Metadata Store (German National Library of Science and Technology)
institution Open Polar
collection DataCite Metadata Store (German National Library of Science and Technology)
op_collection_id ftdatacite
language English
topic Transcriptome or Gene expression
Multiisolate
spellingShingle Transcriptome or Gene expression
Multiisolate
BGI
Physeter macrocephalus Transcriptome or Gene expression
topic_facet Transcriptome or Gene expression
Multiisolate
description Physeter macrocephalus (sperm whale) is being sequenced as an aquatic model organism for the study of respiratory disease, metal toxicity and cancer. Whales are known to accumulate high levels of metals such as chromium, a human lung carcinogen and contributor to other forms of lung disease. Given that the levels of chromium in whale tissue are sufficient to seriously impair or even kill terrestrial mammals, it is hypothesized that marine mammals have evolved novel repair mechanisms that can protect their DNA from metals like chromium. Hypoxia is a well-known cause of respiratory-related diseases such as sleep apnea, chronic obstructive pulmonary disease and pulmonary emphysema. Marine mammals, however, can dive to great depths for prolonged periods of time and not experience these ill effects of hypoxia. The availability of sperm whale genome resources will allow scientists to investigate the molecular pathways contributing to these adaptations.
format Dataset
author BGI
author_facet BGI
author_sort BGI
title Physeter macrocephalus Transcriptome or Gene expression
title_short Physeter macrocephalus Transcriptome or Gene expression
title_full Physeter macrocephalus Transcriptome or Gene expression
title_fullStr Physeter macrocephalus Transcriptome or Gene expression
title_full_unstemmed Physeter macrocephalus Transcriptome or Gene expression
title_sort physeter macrocephalus transcriptome or gene expression
publisher CNGB
publishDate 2012
url https://dx.doi.org/10.26036/cnphis0001086
https://db.cngb.org/search/project/PRJNA177694/
genre Physeter macrocephalus
Sperm whale
genre_facet Physeter macrocephalus
Sperm whale
op_doi https://doi.org/10.26036/cnphis0001086
_version_ 1766168132346445824

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