The branchial microbiome and Neoparamoeba perurans infection ...

• Main Author: Slinger, JC
• Format: Thesis
• Language: unknown
• Published: University Of Tasmania 2023
• Subjects: Atlantic salmon; Salmo salar
• Online Access: https://dx.doi.org/10.25959/23249207.v1; https://figshare.utas.edu.au/articles/thesis/The_branchial_microbiome_and_Neoparamoeba_perurans_infection/23249207/1

Amoebae are unicellular protists distributed throughout terrestrial and aquatic environments. Commonly known as bacterivores or detritivores, members of the Amoebozoa group can parasitise higher vertebrate hosts and cause infectious disease. Furthermore, the virulence of such amoebic infections can in some cases be mediated by the presence of specific bacterial cofactors at the host-pathogen interface. Amoebic gill disease (AGD) remains one of the most significant diseases affecting the productivity of Atlantic salmon (Salmo salar L.) aquaculture, incurring significant costs to the Australian salmonid industry. The aetiological agent Neoparamoeba perurans is a free-living marine amoeba, which colonise gill mucosal surfaces eliciting often fatal branchialitis in affected fish. Although Koch's postulates have been established for AGD, N. perurans is a multi-organism complex of amoeba, a kinetoplastid endosymbiont and associated bacterial consortia. Determination of virulence factors that underpin AGD ...