Antimicrobial peptides : immunomodulatory and therapeutic potential for use in Atlantic salmon (Salmo salar) ...

• Main Author: Blumhardt, M
• Format: Thesis
• Language: unknown
• Published: University Of Tasmania 2023
• Subjects: Atlantic salmon; Salmo salar
• Online Access: https://dx.doi.org/10.25959/23242187.v1; https://figshare.utas.edu.au/articles/thesis/Antimicrobial_peptides_immunomodulatory_and_therapeutic_potential_for_use_in_Atlantic_salmon_Salmo_salar_/23242187/1

The continued use of antibiotics will undoubtedly lead to increases in antibiotic resistant bacteria and decreased effectiveness of antibiotic therapeutics. Therefore, a need exists for new therapeutic agents which effectively treat bacterial outbreaks but limit the ability of microbes to become resistant over time. Antimicrobial peptides are innate defense peptides produced by multicellular organisms to combat a wide variety of pathogens present in the environment. They are naturally produced by the host, exhibit remarkably diverse structures and bioactivity both in and amongst species, and function through a variety of bactericidal mechanisms which limit bacterial resistance. These characteristics make them a potential source for the development of new anti-infective agents. The purpose of this thesis was to assess the antimicrobial activity and stimulatory potential of natural and synthetically derived peptides for use in Atlantic salmon (Salmo salar). In this research, four peptides (P9-4, P11-5, P11-6, ...