Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons
Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction p...
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ftdatacite:10.25384/sage.c.5314574.v1 2023-05-15T15:02:37+02:00 Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons Kine Ø. Hansen Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. 2021 https://dx.doi.org/10.25384/sage.c.5314574.v1 https://sage.figshare.com/collections/Antimicrobial_Activity_of_Securamines_From_the_Bryozoan_i_Securiflustra_securifrons_i_/5314574/1 unknown SAGE Journals https://dx.doi.org/10.1177/1934578x21996180 https://dx.doi.org/10.25384/sage.c.5314574 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 CC-BY 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS Clinical medicine Collection article 2021 ftdatacite https://doi.org/10.25384/sage.c.5314574.v1 https://doi.org/10.1177/1934578x21996180 https://doi.org/10.25384/sage.c.5314574 2021-11-05T12:55:41Z Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan Securiflustra securifrons was found to be active against the human pathogenic bacterium Streptococcus agalactiae (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H – J ( 4 , 5 , and 1-3 ) and the attempt to deconvolute the mode of action of 1 . Article in Journal/Newspaper Arctic DataCite Metadata Store (German National Library of Science and Technology) Arctic |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
unknown |
topic |
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS Clinical medicine |
spellingShingle |
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS Clinical medicine Kine Ø. Hansen Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
topic_facet |
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS Clinical medicine |
description |
Natural products and their derivatives have served as powerful therapeutics against pathogenic microorganisms and are the mainstay of our currently available treatment options to combat infections. As part of our ongoing search for antimicrobial natural products from marine organisms, one fraction prepared from the Arctic marine bryozoan Securiflustra securifrons was found to be active against the human pathogenic bacterium Streptococcus agalactiae (gr. B). Chemical investigation of the fraction revealed that it contained several variants of the highly modified secondary metabolites known as securamines. The securamines are alkaloids sharing a common isoprene-histamine-tryptamine backbone. In this study, we describe the antimicrobial activities of securamine C, E, and H – J ( 4 , 5 , and 1-3 ) and the attempt to deconvolute the mode of action of 1 . |
format |
Article in Journal/Newspaper |
author |
Kine Ø. Hansen Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. |
author_facet |
Kine Ø. Hansen Hansen, Ida K. Ø. Richard, Céline S. Jenssen, Marte Andersen, Jeanette H. Hansen, Espen H. |
author_sort |
Kine Ø. Hansen |
title |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_short |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_full |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_fullStr |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_full_unstemmed |
Antimicrobial Activity of Securamines From the Bryozoan Securiflustra securifrons |
title_sort |
antimicrobial activity of securamines from the bryozoan securiflustra securifrons |
publisher |
SAGE Journals |
publishDate |
2021 |
url |
https://dx.doi.org/10.25384/sage.c.5314574.v1 https://sage.figshare.com/collections/Antimicrobial_Activity_of_Securamines_From_the_Bryozoan_i_Securiflustra_securifrons_i_/5314574/1 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_relation |
https://dx.doi.org/10.1177/1934578x21996180 https://dx.doi.org/10.25384/sage.c.5314574 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.25384/sage.c.5314574.v1 https://doi.org/10.1177/1934578x21996180 https://doi.org/10.25384/sage.c.5314574 |
_version_ |
1766334547879788544 |