Comparison of cytology and human papillomavirus-based primary testing in cervical screening programs in the Nordic countries ...

• Main Authors: Veli-Matti Partanen, Dillner, Joakim, Ameli Tropé, Ágústsson, Ágúst Ingi, Pankakoski, Maiju, Heinävaara, Sirpa, Sarkeala, Tytti, Jiangrong Wang, Skare, Gry Baadstrand, Anttila, Ahti, Lönnberg, Stefan
• Format: Article in Journal/Newspaper
• Language: unknown
• Published: SAGE Journals 2021
• Subjects: 111708 Health and Community Services; FOS: Health sciences; 111402 Obstetrics and Gynaecology; FOS: Clinical medicine; Iceland
• Online Access: https://dx.doi.org/10.25384/sage.c.5300859.v1; https://sage.figshare.com/collections/Comparison_of_cytology_and_human_papillomavirus-based_primary_testing_in_cervical_screening_programs_in_the_Nordic_countries/5300859/1

ObjectiveTo compare primary test positivity in cytology and human papillomavirus-based screening between different Nordic cervical cancer screening programs using harmonized register data.MethodsThis study utilized individual-level data available in national databases in Finland, Iceland, Norway, and Sweden. Cervical test data from each country were converted to standard format and aggregated by calculating the number of test episodes for every test result for each calendar year and one-year age group and test method. Test positivity was estimated as the proportion of positive test results of all primary test episodes with a valid test result for “any positive” and “clearly positive” results.ResultsThe age-adjusted rate ratio for any positive test results in primary human papillomavirus-based screening compared to cytology was 1.66 (95% CI 1.64–1.68). The age-adjusted rate ratio for clearly positive test results was 1.02 (95% CI 1.00–1.05). A decreasing rate ratio by age was seen in both any positive and ...