α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ...
This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree ( Abies sachalinensis ). The resin showed extremely high activity (IC 50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachal...
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ftdatacite:10.25384/sage.c.4555664.v1 2024-09-15T18:32:48+00:00 α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... Nakagawa, Toshinori Ashour, Ahmed Yhiya Amen Koba, Yurie Ohnuki, Koichiro Kuniyoshi Shimizu 2019 https://dx.doi.org/10.25384/sage.c.4555664.v1 https://sage.figshare.com/collections/_-Glucosidase_Inhibitory_Activity_of_Resin_From_Sakhalin_fir_Tree_i_Abies_sachalinensis_i_and_its_Bioactive_Compounds/4555664/1 unknown Figshare https://dx.doi.org/10.1177/1934578x19858460 https://dx.doi.org/10.25384/sage.c.4555664 CC BY 4.0 https://creativecommons.org/licenses/by/4.0 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS: Clinical medicine Collection article 2019 ftdatacite https://doi.org/10.25384/sage.c.4555664.v110.1177/1934578x1985846010.25384/sage.c.4555664 2024-09-02T09:51:42Z This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree ( Abies sachalinensis ). The resin showed extremely high activity (IC 50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds—(holophyllane C ( 1 ), (−) - (24 E )-23-oxo-3,4- seco -9β H -lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid ( 2 ), abiesonic acid ( 3 ), (−) - (24 E )-23-oxo-3,4- seco -9β H -lanosta-4(28),7,24-triene-3,26-dioic acid ( 4 ), 3,4- seco -4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid ( 5 ), and (−) - abiesonic acid 3-methyl ester ( 6 ))—showed high activity (their IC 50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin’s α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new ... Article in Journal/Newspaper Sakhalin DataCite |
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111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS: Clinical medicine |
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111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS: Clinical medicine Nakagawa, Toshinori Ashour, Ahmed Yhiya Amen Koba, Yurie Ohnuki, Koichiro Kuniyoshi Shimizu α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... |
topic_facet |
111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified FOS: Clinical medicine |
description |
This study investigated in vitro the α-glucosidase inhibitory activity of resin from the Sakhalin fir tree ( Abies sachalinensis ). The resin showed extremely high activity (IC 50 of 17.3 µg/mL). We isolated 8 compounds from the resin and identified them. All of the compounds isolated from A. sachalinensis resin are reported for the first time in the present study. In an α-glucosidase inhibitory assay, 6 compounds—(holophyllane C ( 1 ), (−) - (24 E )-23-oxo-3,4- seco -9β H -lanosta-4(28),6,8(14),24-tetraen-3,26-dioic acid ( 2 ), abiesonic acid ( 3 ), (−) - (24 E )-23-oxo-3,4- seco -9β H -lanosta-4(28),7,24-triene-3,26-dioic acid ( 4 ), 3,4- seco -4(28),6,8(14),22Z,24-mariesapentaen-26,23-olide-3-oic acid ( 5 ), and (−) - abiesonic acid 3-methyl ester ( 6 ))—showed high activity (their IC 50 values were 25.1, 20.9, 82.4, 20.5, 27.3, and 20.5 µg/mL, respectively). These compounds should contribute to the resin’s α-glucosidase inhibitory activity. From an industrial point of view, these findings provide new ... |
format |
Article in Journal/Newspaper |
author |
Nakagawa, Toshinori Ashour, Ahmed Yhiya Amen Koba, Yurie Ohnuki, Koichiro Kuniyoshi Shimizu |
author_facet |
Nakagawa, Toshinori Ashour, Ahmed Yhiya Amen Koba, Yurie Ohnuki, Koichiro Kuniyoshi Shimizu |
author_sort |
Nakagawa, Toshinori |
title |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... |
title_short |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... |
title_full |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... |
title_fullStr |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... |
title_full_unstemmed |
α-Glucosidase Inhibitory Activity of Resin From Sakhalin fir Tree ( Abies sachalinensis ) and its Bioactive Compounds ... |
title_sort |
α-glucosidase inhibitory activity of resin from sakhalin fir tree ( abies sachalinensis ) and its bioactive compounds ... |
publisher |
Figshare |
publishDate |
2019 |
url |
https://dx.doi.org/10.25384/sage.c.4555664.v1 https://sage.figshare.com/collections/_-Glucosidase_Inhibitory_Activity_of_Resin_From_Sakhalin_fir_Tree_i_Abies_sachalinensis_i_and_its_Bioactive_Compounds/4555664/1 |
genre |
Sakhalin |
genre_facet |
Sakhalin |
op_relation |
https://dx.doi.org/10.1177/1934578x19858460 https://dx.doi.org/10.25384/sage.c.4555664 |
op_rights |
CC BY 4.0 https://creativecommons.org/licenses/by/4.0 |
op_doi |
https://doi.org/10.25384/sage.c.4555664.v110.1177/1934578x1985846010.25384/sage.c.4555664 |
_version_ |
1810474548836958208 |