Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ...
AIMS/HYPOTHESIS: The common muscle-specific TBC1D4 p.Arg684Ter loss-of-function variant defines a subtype of non-autoimmune diabetes in Arctic populations. Homozygous carriers are characterised by elevated postprandial glucose and insulin levels. Because 3.8% of the Greenlandic population are homozy...
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2021
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Online Access: | https://dx.doi.org/10.17863/cam.69310 https://www.repository.cam.ac.uk/handle/1810/321851 |
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ftdatacite:10.17863/cam.69310 2024-02-27T08:37:45+00:00 Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... Schnurr, Theresia M Jørsboe, Emil Chadt, Alexandra Dahl-Petersen, Inger K Kristensen, Jonas M Wojtaszewski, Jørgen FP Springer, Christian Bjerregaard, Peter Brage, Søren Pedersen, Oluf Moltke, Ida Grarup, Niels Al-Hasani, Hadi Albrechtsen, Anders Jørgensen, Marit E Hansen, Torben 2021 https://dx.doi.org/10.17863/cam.69310 https://www.repository.cam.ac.uk/handle/1810/321851 en eng Springer Science and Business Media LLC open.access Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 http://purl.org/coar/access_right/c_abf2 Arctic Gene-environment interaction Lifestyle therapy Physical activity Postprandial hyperglycaemia TBC1D4 loss-of-function Adult Blood Glucose Diabetes Mellitus, Type 2 Exercise Female GTPase-Activating Proteins Gene-Environment Interaction Genetic Predisposition to Disease Genotyping Techniques Glucose Tolerance Test Greenland Humans Hyperglycemia Insulin Inuit Life Style Loss of Function Mutation Male Middle Aged Postprandial Period article-journal ScholarlyArticle JournalArticle Article 2021 ftdatacite https://doi.org/10.17863/cam.69310 2024-02-01T14:59:38Z AIMS/HYPOTHESIS: The common muscle-specific TBC1D4 p.Arg684Ter loss-of-function variant defines a subtype of non-autoimmune diabetes in Arctic populations. Homozygous carriers are characterised by elevated postprandial glucose and insulin levels. Because 3.8% of the Greenlandic population are homozygous carriers, it is important to explore possibilities for precision medicine. We aimed to investigate whether physical activity attenuates the effect of this variant on 2 h plasma glucose levels after an oral glucose load. METHODS: In a Greenlandic population cohort (n = 2655), 2 h plasma glucose levels were obtained after an OGTT, physical activity was estimated as physical activity energy expenditure and TBC1D4 genotype was determined. We performed TBC1D4-physical activity interaction analysis, applying a linear mixed model to correct for genetic admixture and relatedness. RESULTS: Physical activity was inversely associated with 2 h plasma glucose levels (β[main effect of physical activity] -0.0033 [mmol/l] / ... Article in Journal/Newspaper Arctic Greenland greenlandic inuit DataCite Metadata Store (German National Library of Science and Technology) Arctic Greenland |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
Arctic Gene-environment interaction Lifestyle therapy Physical activity Postprandial hyperglycaemia TBC1D4 loss-of-function Adult Blood Glucose Diabetes Mellitus, Type 2 Exercise Female GTPase-Activating Proteins Gene-Environment Interaction Genetic Predisposition to Disease Genotyping Techniques Glucose Tolerance Test Greenland Humans Hyperglycemia Insulin Inuit Life Style Loss of Function Mutation Male Middle Aged Postprandial Period |
spellingShingle |
Arctic Gene-environment interaction Lifestyle therapy Physical activity Postprandial hyperglycaemia TBC1D4 loss-of-function Adult Blood Glucose Diabetes Mellitus, Type 2 Exercise Female GTPase-Activating Proteins Gene-Environment Interaction Genetic Predisposition to Disease Genotyping Techniques Glucose Tolerance Test Greenland Humans Hyperglycemia Insulin Inuit Life Style Loss of Function Mutation Male Middle Aged Postprandial Period Schnurr, Theresia M Jørsboe, Emil Chadt, Alexandra Dahl-Petersen, Inger K Kristensen, Jonas M Wojtaszewski, Jørgen FP Springer, Christian Bjerregaard, Peter Brage, Søren Pedersen, Oluf Moltke, Ida Grarup, Niels Al-Hasani, Hadi Albrechtsen, Anders Jørgensen, Marit E Hansen, Torben Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... |
topic_facet |
Arctic Gene-environment interaction Lifestyle therapy Physical activity Postprandial hyperglycaemia TBC1D4 loss-of-function Adult Blood Glucose Diabetes Mellitus, Type 2 Exercise Female GTPase-Activating Proteins Gene-Environment Interaction Genetic Predisposition to Disease Genotyping Techniques Glucose Tolerance Test Greenland Humans Hyperglycemia Insulin Inuit Life Style Loss of Function Mutation Male Middle Aged Postprandial Period |
description |
AIMS/HYPOTHESIS: The common muscle-specific TBC1D4 p.Arg684Ter loss-of-function variant defines a subtype of non-autoimmune diabetes in Arctic populations. Homozygous carriers are characterised by elevated postprandial glucose and insulin levels. Because 3.8% of the Greenlandic population are homozygous carriers, it is important to explore possibilities for precision medicine. We aimed to investigate whether physical activity attenuates the effect of this variant on 2 h plasma glucose levels after an oral glucose load. METHODS: In a Greenlandic population cohort (n = 2655), 2 h plasma glucose levels were obtained after an OGTT, physical activity was estimated as physical activity energy expenditure and TBC1D4 genotype was determined. We performed TBC1D4-physical activity interaction analysis, applying a linear mixed model to correct for genetic admixture and relatedness. RESULTS: Physical activity was inversely associated with 2 h plasma glucose levels (β[main effect of physical activity] -0.0033 [mmol/l] / ... |
format |
Article in Journal/Newspaper |
author |
Schnurr, Theresia M Jørsboe, Emil Chadt, Alexandra Dahl-Petersen, Inger K Kristensen, Jonas M Wojtaszewski, Jørgen FP Springer, Christian Bjerregaard, Peter Brage, Søren Pedersen, Oluf Moltke, Ida Grarup, Niels Al-Hasani, Hadi Albrechtsen, Anders Jørgensen, Marit E Hansen, Torben |
author_facet |
Schnurr, Theresia M Jørsboe, Emil Chadt, Alexandra Dahl-Petersen, Inger K Kristensen, Jonas M Wojtaszewski, Jørgen FP Springer, Christian Bjerregaard, Peter Brage, Søren Pedersen, Oluf Moltke, Ida Grarup, Niels Al-Hasani, Hadi Albrechtsen, Anders Jørgensen, Marit E Hansen, Torben |
author_sort |
Schnurr, Theresia M |
title |
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... |
title_short |
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... |
title_full |
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... |
title_fullStr |
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... |
title_full_unstemmed |
Physical activity attenuates postprandial hyperglycaemia in homozygous TBC1D4 loss-of-function mutation carriers. ... |
title_sort |
physical activity attenuates postprandial hyperglycaemia in homozygous tbc1d4 loss-of-function mutation carriers. ... |
publisher |
Springer Science and Business Media LLC |
publishDate |
2021 |
url |
https://dx.doi.org/10.17863/cam.69310 https://www.repository.cam.ac.uk/handle/1810/321851 |
geographic |
Arctic Greenland |
geographic_facet |
Arctic Greenland |
genre |
Arctic Greenland greenlandic inuit |
genre_facet |
Arctic Greenland greenlandic inuit |
op_rights |
open.access Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/10.17863/cam.69310 |
_version_ |
1792044714778689536 |