Associations Between Maternal Prenatal C-Reactive Protein and Risk Factors for Psychosis in Adolescent Offspring: Findings From the Northern Finland Birth Cohort 1986. ...

• Main Authors: Ramsay, Hugh, Surcel, Heljä-Marja, Björnholm, Lassi, Kerkelä, Martta, Khandaker, Golam M, Veijola, Juha
• Format: Article in Journal/Newspaper
• Language: English
• Published: Oxford University Press (OUP) 2021
• Subjects: CRP; birth cohort; cannabis; inflammation; psychotic experiences; Academic Success; Adolescent; Adolescent Behavior; Adult; C-Reactive Protein; Child; Female; Finland; Humans; Inflammation; Longitudinal Studies; Male; Marijuana Use; Pregnancy; Prenatal Exposure Delayed Effects; Psychotic Disorders; Risk Factors; Northern Finland
• Online Access: https://dx.doi.org/10.17863/cam.57799; https://www.repository.cam.ac.uk/handle/1810/310709

Prenatal infection is associated with brain structural and functional abnormalities and may increase the risk for psychosis through a direct effect on neurodevelopment. Various infections may exert their effect through a proinflammatory immune response but studies of prenatal maternal inflammatory markers and offspring neurodevelopment are scarce. Using the longitudinal Northern Finland Birth Cohort 1986 study, we examined the associations of maternal prenatal C-reactive protein (CRP) levels with psychosis risk factors in adolescent offspring. CRP was measured in maternal sera collected in pregnancy. In offspring, school performance was measured at age 7 years, while school performance, psychotic experiences, and cannabis use were measured at age 16 years. We tested associations of CRP with offspring measures using regression analysis controlling for offspring sex, maternal education level, and prenatal maternal body mass index, smoking and alcohol use in pregnancy, place of birth, maternal psychiatric ...