Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ...
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based test...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article in Journal/Newspaper |
Language: | English |
Published: |
OUP
2018
|
Subjects: | |
Online Access: | https://dx.doi.org/10.17863/cam.30345 https://www.repository.cam.ac.uk/handle/1810/282983 |
id |
ftdatacite:10.17863/cam.30345 |
---|---|
record_format |
openpolar |
spelling |
ftdatacite:10.17863/cam.30345 2024-02-27T08:43:49+00:00 Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... Teslovich, Tanya M Kim, Daniel Seung Yin, Xianyong Stancáková, Alena Jackson, Anne U Wielscher, Matthias Naj, Adam Perry, John RB Huyghe, Jeroen R Stringham, Heather M Davis, James P Raulerson, Chelsea K Welch, Ryan P Fuchsberger, Christian Locke, Adam E Sim, Xueling Chines, Peter S Narisu, Narisu Kangas, Antti J Soininen, Pasi Genetics Of Obesity-Related Liver Disease Consortium GOLD, The Alzheimer's Disease Genetics Consortium ADGC, The DIAbetes Genetics Replication And Meta-Analysis DIAGRAM Ala-Korpela, Mika Gudnason, Vilmundur Musani, Solomon K Jarvelin, Marjo-Riitta Schellenberg, Gerard D Speliotes, Elizabeth K Kuusisto, Johanna Collins, Francis S Boehnke, Michael Laakso, Markku Mohlke, Karen L 2018 https://dx.doi.org/10.17863/cam.30345 https://www.repository.cam.ac.uk/handle/1810/282983 en eng OUP Amino Acids Finland Gene Frequency Genome-Wide Association Study Genotype Humans Male Middle Aged article-journal ScholarlyArticle JournalArticle Article 2018 ftdatacite https://doi.org/10.17863/cam.30345 2024-02-01T14:52:39Z Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based tests of association between nine serum amino acids (alanine, glutamine, glycine, histidine, isoleucine, leucine, phenylalanine, tyrosine, and valine) and 16.6 million genotyped and imputed variants in 8545 non-diabetic Finnish men from the METabolic Syndrome In Men (METSIM) study with replication in Northern Finland Birth Cohort (NFBC1966). We identified five novel loci associated with amino acid levels (P = < 5×10-8): LOC157273/PPP1R3B with glycine (rs9987289, P = 2.3×10-26); ZFHX3 (chr16:73326579, minor allele frequency (MAF) = 0.42%, P = 3.6×10-9), LIPC (rs10468017, P = 1.5×10-8), and WWOX (rs9937914, P = 3.8×10-8) with alanine; and TRIB1 with tyrosine (rs28601761, P = 8×10-9). Gene-based tests identified two ... Article in Journal/Newspaper Northern Finland DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
Amino Acids Finland Gene Frequency Genome-Wide Association Study Genotype Humans Male Middle Aged |
spellingShingle |
Amino Acids Finland Gene Frequency Genome-Wide Association Study Genotype Humans Male Middle Aged Teslovich, Tanya M Kim, Daniel Seung Yin, Xianyong Stancáková, Alena Jackson, Anne U Wielscher, Matthias Naj, Adam Perry, John RB Huyghe, Jeroen R Stringham, Heather M Davis, James P Raulerson, Chelsea K Welch, Ryan P Fuchsberger, Christian Locke, Adam E Sim, Xueling Chines, Peter S Narisu, Narisu Kangas, Antti J Soininen, Pasi Genetics Of Obesity-Related Liver Disease Consortium GOLD, The Alzheimer's Disease Genetics Consortium ADGC, The DIAbetes Genetics Replication And Meta-Analysis DIAGRAM Ala-Korpela, Mika Gudnason, Vilmundur Musani, Solomon K Jarvelin, Marjo-Riitta Schellenberg, Gerard D Speliotes, Elizabeth K Kuusisto, Johanna Collins, Francis S Boehnke, Michael Laakso, Markku Mohlke, Karen L Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... |
topic_facet |
Amino Acids Finland Gene Frequency Genome-Wide Association Study Genotype Humans Male Middle Aged |
description |
Comprehensive metabolite profiling captures many highly heritable traits, including amino acid levels, which are potentially sensitive biomarkers for disease pathogenesis. To better understand the contribution of genetic variation to amino acid levels, we performed single variant and gene-based tests of association between nine serum amino acids (alanine, glutamine, glycine, histidine, isoleucine, leucine, phenylalanine, tyrosine, and valine) and 16.6 million genotyped and imputed variants in 8545 non-diabetic Finnish men from the METabolic Syndrome In Men (METSIM) study with replication in Northern Finland Birth Cohort (NFBC1966). We identified five novel loci associated with amino acid levels (P = < 5×10-8): LOC157273/PPP1R3B with glycine (rs9987289, P = 2.3×10-26); ZFHX3 (chr16:73326579, minor allele frequency (MAF) = 0.42%, P = 3.6×10-9), LIPC (rs10468017, P = 1.5×10-8), and WWOX (rs9937914, P = 3.8×10-8) with alanine; and TRIB1 with tyrosine (rs28601761, P = 8×10-9). Gene-based tests identified two ... |
format |
Article in Journal/Newspaper |
author |
Teslovich, Tanya M Kim, Daniel Seung Yin, Xianyong Stancáková, Alena Jackson, Anne U Wielscher, Matthias Naj, Adam Perry, John RB Huyghe, Jeroen R Stringham, Heather M Davis, James P Raulerson, Chelsea K Welch, Ryan P Fuchsberger, Christian Locke, Adam E Sim, Xueling Chines, Peter S Narisu, Narisu Kangas, Antti J Soininen, Pasi Genetics Of Obesity-Related Liver Disease Consortium GOLD, The Alzheimer's Disease Genetics Consortium ADGC, The DIAbetes Genetics Replication And Meta-Analysis DIAGRAM Ala-Korpela, Mika Gudnason, Vilmundur Musani, Solomon K Jarvelin, Marjo-Riitta Schellenberg, Gerard D Speliotes, Elizabeth K Kuusisto, Johanna Collins, Francis S Boehnke, Michael Laakso, Markku Mohlke, Karen L |
author_facet |
Teslovich, Tanya M Kim, Daniel Seung Yin, Xianyong Stancáková, Alena Jackson, Anne U Wielscher, Matthias Naj, Adam Perry, John RB Huyghe, Jeroen R Stringham, Heather M Davis, James P Raulerson, Chelsea K Welch, Ryan P Fuchsberger, Christian Locke, Adam E Sim, Xueling Chines, Peter S Narisu, Narisu Kangas, Antti J Soininen, Pasi Genetics Of Obesity-Related Liver Disease Consortium GOLD, The Alzheimer's Disease Genetics Consortium ADGC, The DIAbetes Genetics Replication And Meta-Analysis DIAGRAM Ala-Korpela, Mika Gudnason, Vilmundur Musani, Solomon K Jarvelin, Marjo-Riitta Schellenberg, Gerard D Speliotes, Elizabeth K Kuusisto, Johanna Collins, Francis S Boehnke, Michael Laakso, Markku Mohlke, Karen L |
author_sort |
Teslovich, Tanya M |
title |
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... |
title_short |
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... |
title_full |
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... |
title_fullStr |
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... |
title_full_unstemmed |
Identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 Finnish men from the METSIM study. ... |
title_sort |
identification of seven novel loci associated with amino acid levels using single-variant and gene-based tests in 8545 finnish men from the metsim study. ... |
publisher |
OUP |
publishDate |
2018 |
url |
https://dx.doi.org/10.17863/cam.30345 https://www.repository.cam.ac.uk/handle/1810/282983 |
genre |
Northern Finland |
genre_facet |
Northern Finland |
op_doi |
https://doi.org/10.17863/cam.30345 |
_version_ |
1792051883839324160 |