Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ...
OBJECTIVE: Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome and antimicrobial resistance (AMR) gene profiles in critically ill children treated w...
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ftdatacite:10.17863/cam.105447 2024-02-27T08:38:06+00:00 Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... Kean, Iain Robert Louis Clark, John A Zhang, Zhenguang Daubney, Esther White, Deborah Ferrando-Vivas, Paloma Milla, Gema Cuthbertson, Brian Pappachan, John Klein, Nigel Mouncey, Paul Rowan, Kathy Myburgh, John Gouliouris, Theodore Baker, Stephen Parkhill, Julian Pathan, Nazima Arctic Research Team 2024 https://dx.doi.org/10.17863/cam.105447 https://www.repository.cam.ac.uk/handle/1810/363335 en eng BMJ open.access Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 http://purl.org/coar/access_right/c_abf2 ANTIBIOTIC THERAPY DRUG RESISTANCE article-journal ScholarlyArticle JournalArticle Article 2024 ftdatacite https://doi.org/10.17863/cam.105447 2024-02-01T16:56:12Z OBJECTIVE: Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome and antimicrobial resistance (AMR) gene profiles in critically ill children treated with SDD-enhanced infection control compared with conventional infection control. DESIGN: We conducted shotgun metagenomic microbiome and resistome analysis on serial oropharyngeal and faecal samples collected from critically ill, mechanically ventilated patients in a pilot multicentre cluster randomised trial of SDD. The microbiome and AMR profiles were compared for longitudinal and intergroup changes. Of consented patients, faecal microbiome baseline samples were obtained in 89 critically ill children. Additionally, samples collected during and after critical illness were collected in 17 children treated with SDD-enhanced infection control and 19 children who received standard care. RESULTS: SDD affected the ... Article in Journal/Newspaper Arctic DataCite Metadata Store (German National Library of Science and Technology) Arctic |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
ANTIBIOTIC THERAPY DRUG RESISTANCE |
spellingShingle |
ANTIBIOTIC THERAPY DRUG RESISTANCE Kean, Iain Robert Louis Clark, John A Zhang, Zhenguang Daubney, Esther White, Deborah Ferrando-Vivas, Paloma Milla, Gema Cuthbertson, Brian Pappachan, John Klein, Nigel Mouncey, Paul Rowan, Kathy Myburgh, John Gouliouris, Theodore Baker, Stephen Parkhill, Julian Pathan, Nazima Arctic Research Team Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... |
topic_facet |
ANTIBIOTIC THERAPY DRUG RESISTANCE |
description |
OBJECTIVE: Selective decontamination of the digestive tract (SDD) is a well-studied but hotly contested medical intervention of enhanced infection control. Here, we aim to characterise the changes to the microbiome and antimicrobial resistance (AMR) gene profiles in critically ill children treated with SDD-enhanced infection control compared with conventional infection control. DESIGN: We conducted shotgun metagenomic microbiome and resistome analysis on serial oropharyngeal and faecal samples collected from critically ill, mechanically ventilated patients in a pilot multicentre cluster randomised trial of SDD. The microbiome and AMR profiles were compared for longitudinal and intergroup changes. Of consented patients, faecal microbiome baseline samples were obtained in 89 critically ill children. Additionally, samples collected during and after critical illness were collected in 17 children treated with SDD-enhanced infection control and 19 children who received standard care. RESULTS: SDD affected the ... |
format |
Article in Journal/Newspaper |
author |
Kean, Iain Robert Louis Clark, John A Zhang, Zhenguang Daubney, Esther White, Deborah Ferrando-Vivas, Paloma Milla, Gema Cuthbertson, Brian Pappachan, John Klein, Nigel Mouncey, Paul Rowan, Kathy Myburgh, John Gouliouris, Theodore Baker, Stephen Parkhill, Julian Pathan, Nazima Arctic Research Team |
author_facet |
Kean, Iain Robert Louis Clark, John A Zhang, Zhenguang Daubney, Esther White, Deborah Ferrando-Vivas, Paloma Milla, Gema Cuthbertson, Brian Pappachan, John Klein, Nigel Mouncey, Paul Rowan, Kathy Myburgh, John Gouliouris, Theodore Baker, Stephen Parkhill, Julian Pathan, Nazima Arctic Research Team |
author_sort |
Kean, Iain Robert Louis |
title |
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... |
title_short |
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... |
title_full |
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... |
title_fullStr |
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... |
title_full_unstemmed |
Short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the ARCTIC Study). ... |
title_sort |
short-duration selective decontamination of the digestive tract infection control does not contribute to increased antimicrobial resistance burden in a pilot cluster randomised trial (the arctic study). ... |
publisher |
BMJ |
publishDate |
2024 |
url |
https://dx.doi.org/10.17863/cam.105447 https://www.repository.cam.ac.uk/handle/1810/363335 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic |
genre_facet |
Arctic |
op_rights |
open.access Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 http://purl.org/coar/access_right/c_abf2 |
op_doi |
https://doi.org/10.17863/cam.105447 |
_version_ |
1792045028968759296 |