ARTICA RCT primary outcome ...

• Main Author: Camaro, C
• Format: Dataset
• Language: English
• Published: DANS Data Station Life Sciences 2019
• Subjects: artica
• Online Access: https://dx.doi.org/10.17026/dans-xd2-3zpg; https://lifesciences.datastations.nl/citation?persistentId=doi:10.17026/dans-xd2-3zpg

BACKGROUND: Patients with suspected non-ST-segment elevation acute coronary syndrome (NSTE-ACS) are routinely transferred to theemergency department (ED). A clinical risk score with point-of-care (POC) troponin measurement might enable ambulance paramedics to identify low-risk patients in whom ED evaluation is unnecessary. The aim was to assess safety and healthcare costs of a pre-hospital rule-out strategy using a POC troponin measurement in low-risk suspected NSTE-ACS patients.METHODS AND RESULTS:This investigator-initiated, randomized clinical trial was conducted in five ambulance regions in the Netherlands. Suspected NSTE-ACS patients with HEAR (History, ECG, Age, Risk factors) score ≤3 were randomized to pre-hospital rule-out with POC troponin measurement or direct transfer to the ED. The sample size calculation was based on the primary outcome of 30-day healthcare costs. Secondary outcome was safety, defined as 30-day major adverse cardiac events (MACE), consisting of ACS, unplanned revascularization ...