Seawater carbonate chemistry and carbamazepine bioaccumulation of Mytilus galloprovincialis ...

• Main Authors: Mezzelani, Marica, Nardi, Alessandro, Bernardini, Ilaria, Milan, Massimo, Peruzza, Luca, d'Errico, Giuseppe, Fattorini, Daniele, Gorbi, Stefania, Patarnello, Tomaso, Regoli, Francesco
• Format: Dataset
• Language: English
• Published: PANGAEA 2021
• Subjects: Animalia; Benthic animals; Benthos; Coast and continental shelf; Containers and aquaria 20-1000 L or < 1 m**2; Immunology/Self-protection; Laboratory experiment; Mediterranean Sea; Mollusca; Mytilus galloprovincialis; Organic toxins; Other metabolic rates; Other studied parameter or process; Single species; Temperate; Type; Species; Registration number of species; Uniform resource locator/link to reference; Experiment duration; Treatment; Sample code/label; Salinity; Salinity, standard deviation; Temperature, water; Temperature, water, standard deviation; pH; pH, standard deviation; Alkalinity, total; Alkalinity, total, standard deviation; Partial pressure of carbon dioxide water at sea surface temperature wet air; Partial pressure of carbon dioxide, standard deviation; Calcite saturation state; Calcite saturation state, standard deviation; Aragonite saturation state; Aragonite saturation state, standard deviation; Carbamazepine, per dry mass; Carbamazepine, standard deviation; Hemocytes lysosomal membranes stability; Hemocytes lysosomal membranes stability, standard error; Granulocytes/Hyalinocytes ratio; Granulocytes/Hyalinocytes ratio, standard error; Phagocytosis; Phagocytosis, standard error; Acetylcholinesterase activity, per protein mass; Acetylcholinesterase activity, per protein mass, standard error; Hemocytes micronuclei frequency; Hemocytes micronuclei frequency, standard error; DNA fragmentation; DNA fragmentation, standard error; Ocean acidification
• Online Access: https://dx.doi.org/10.1594/pangaea.930496; https://doi.pangaea.de/10.1594/PANGAEA.930496

Contaminants of emerging concern and ocean changes are key environmental stressors for marine species with possibly synergistic, but still unexplored, deleterious effects. In the present study the influence of a simulated ocean acidification scenario (pH = 7.6) was investigated on metabolism and sub-lethal effects of carbamazepine, CBZ (1 µg/L), chosen as one of the most widely diffused pharmaceuticals in marine organisms. A multidisciplinary approach was applied on mussels, M. galloprovincialis, integrating measurement of drug bioaccumulation with changes in the whole transcriptome, responsiveness of various biochemical and cellular biomarkers including immunological parameters, lipid and oxidative metabolism, onset of genotoxic effects. Chemical analyses revealed a limited influence of hypercapnia on accumulation and excretion of CBZ, while a complex network of biological responses was observed in gene expression profile and functional changes at cellular level. The modulation of gamma-aminobutyric acid ... : In order to allow full comparability with other ocean acidification data sets, the R package seacarb (Gattuso et al, 2021) was used to compute a complete and consistent set of carbonate system variables, as described by Nisumaa et al. (2010). In this dataset the original values were archived in addition with the recalculated parameters (see related PI). The date of carbonate chemistry calculation by seacarb is 2021-04-19. ...