(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80
We assessed the relationship between exposure to organohalogen polluted minke whale (Balaenoptera acutorostrata) blubber and liver morphology and function in a generational controlled study of 28 Greenland sledge dogs (Canis familiaris). The prevalence of portal fibrosis, mild bile duct hyperplasia,...
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ftdatacite:10.1594/pangaea.837324 2023-05-15T12:58:31+02:00 (Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 Sonne, Christian Leifsson, Pall S Dietz, Rune Kirkegaard, Maja Jensen, A Shahmiri, Soheila Letcher, Robert J 2008 text/tab-separated-values https://dx.doi.org/10.1594/pangaea.837324 https://doi.pangaea.de/10.1594/PANGAEA.837324 en eng PANGAEA - Data Publisher for Earth & Environmental Science https://dx.doi.org/10.1016/j.envres.2007.08.010 Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 CC-BY Species Treatment Liver, mass Standard deviation Sample amount, subset Bilirubin Bile acids Alanine aminotransferase Alkaline phosphatase Aspartate aminotransferase Lactate dehydrogenase Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Biological sample International Polar Year 2007-2008 IPY Supplementary Dataset dataset Dataset 2008 ftdatacite https://doi.org/10.1594/pangaea.837324 https://doi.org/10.1016/j.envres.2007.08.010 2021-11-05T12:55:41Z We assessed the relationship between exposure to organohalogen polluted minke whale (Balaenoptera acutorostrata) blubber and liver morphology and function in a generational controlled study of 28 Greenland sledge dogs (Canis familiaris). The prevalence of portal fibrosis, mild bile duct hyperplasia, and vascular leukocyte infiltrations was significantly higher in the exposed group (all Chi-square: p<0.05). In case of granulomas, the frequency was significantly highest in the bitches (P generation) while the prevalence of portal fibrosis was highest in the F generation (pups) (both Chi-square: p<0.05). No significant difference between exposed and controls was found for bile acid, ALAT, and ALKP, while ASAT and LDH were significantly highest in the control group (both ANOVA: p<0.05). We therefore suggest that a daily intake of 50-200 g environmentally organohalogen polluted minke whale blubber can cause liver lesions in Greenland sledge dogs. It is reasonable to infer that other apex predators such as polar bears (Ursus maritimus) and humans may suffer from similar impacts. : Exposed group: exposed to 50-200 g polluted minke whale blubber for 336-658 days. PCB measured per lipid weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 Dataset Aasiaat Balaenoptera acutorostrata Greenland International Polar Year IPY minke whale Ursus maritimus DataCite Metadata Store (German National Library of Science and Technology) Aasiaat ENVELOPE(-52.800,-52.800,68.700,68.700) Dietz ENVELOPE(-153.167,-153.167,-86.267,-86.267) Greenland |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
Species Treatment Liver, mass Standard deviation Sample amount, subset Bilirubin Bile acids Alanine aminotransferase Alkaline phosphatase Aspartate aminotransferase Lactate dehydrogenase Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Biological sample International Polar Year 2007-2008 IPY |
spellingShingle |
Species Treatment Liver, mass Standard deviation Sample amount, subset Bilirubin Bile acids Alanine aminotransferase Alkaline phosphatase Aspartate aminotransferase Lactate dehydrogenase Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Biological sample International Polar Year 2007-2008 IPY Sonne, Christian Leifsson, Pall S Dietz, Rune Kirkegaard, Maja Jensen, A Shahmiri, Soheila Letcher, Robert J (Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 |
topic_facet |
Species Treatment Liver, mass Standard deviation Sample amount, subset Bilirubin Bile acids Alanine aminotransferase Alkaline phosphatase Aspartate aminotransferase Lactate dehydrogenase Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Biological sample International Polar Year 2007-2008 IPY |
description |
We assessed the relationship between exposure to organohalogen polluted minke whale (Balaenoptera acutorostrata) blubber and liver morphology and function in a generational controlled study of 28 Greenland sledge dogs (Canis familiaris). The prevalence of portal fibrosis, mild bile duct hyperplasia, and vascular leukocyte infiltrations was significantly higher in the exposed group (all Chi-square: p<0.05). In case of granulomas, the frequency was significantly highest in the bitches (P generation) while the prevalence of portal fibrosis was highest in the F generation (pups) (both Chi-square: p<0.05). No significant difference between exposed and controls was found for bile acid, ALAT, and ALKP, while ASAT and LDH were significantly highest in the control group (both ANOVA: p<0.05). We therefore suggest that a daily intake of 50-200 g environmentally organohalogen polluted minke whale blubber can cause liver lesions in Greenland sledge dogs. It is reasonable to infer that other apex predators such as polar bears (Ursus maritimus) and humans may suffer from similar impacts. : Exposed group: exposed to 50-200 g polluted minke whale blubber for 336-658 days. PCB measured per lipid weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 |
format |
Dataset |
author |
Sonne, Christian Leifsson, Pall S Dietz, Rune Kirkegaard, Maja Jensen, A Shahmiri, Soheila Letcher, Robert J |
author_facet |
Sonne, Christian Leifsson, Pall S Dietz, Rune Kirkegaard, Maja Jensen, A Shahmiri, Soheila Letcher, Robert J |
author_sort |
Sonne, Christian |
title |
(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 |
title_short |
(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 |
title_full |
(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 |
title_fullStr |
(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 |
title_full_unstemmed |
(Table 3) Liver weight, blood liver parameters, and blood plasma PCB concentrations in 14 sledge dog bitches and their 14 pups in Aasiaat, west Greenland, supplement to: Sonne, Christian; Leifsson, Pall S; Dietz, Rune; Kirkegaard, Maja; Jensen, A; Shahmiri, Soheila; Letcher, Robert J (2008): Greenland sledge dogs (Canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. Environmental Research, 106(1), 72-80 |
title_sort |
(table 3) liver weight, blood liver parameters, and blood plasma pcb concentrations in 14 sledge dog bitches and their 14 pups in aasiaat, west greenland, supplement to: sonne, christian; leifsson, pall s; dietz, rune; kirkegaard, maja; jensen, a; shahmiri, soheila; letcher, robert j (2008): greenland sledge dogs (canis familiaris) develop liver lesions when exposed to a chronic and dietary low dose of an environmental organohalogen cocktail. environmental research, 106(1), 72-80 |
publisher |
PANGAEA - Data Publisher for Earth & Environmental Science |
publishDate |
2008 |
url |
https://dx.doi.org/10.1594/pangaea.837324 https://doi.pangaea.de/10.1594/PANGAEA.837324 |
long_lat |
ENVELOPE(-52.800,-52.800,68.700,68.700) ENVELOPE(-153.167,-153.167,-86.267,-86.267) |
geographic |
Aasiaat Dietz Greenland |
geographic_facet |
Aasiaat Dietz Greenland |
genre |
Aasiaat Balaenoptera acutorostrata Greenland International Polar Year IPY minke whale Ursus maritimus |
genre_facet |
Aasiaat Balaenoptera acutorostrata Greenland International Polar Year IPY minke whale Ursus maritimus |
op_relation |
https://dx.doi.org/10.1016/j.envres.2007.08.010 |
op_rights |
Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1594/pangaea.837324 https://doi.org/10.1016/j.envres.2007.08.010 |
_version_ |
1766281088598016000 |