Bone metabolic and hormonal characteristics of Australian Antarctic expeditioners ...

• Main Authors: Iuliano-Burns, Sandra, Wang, X F, Ayton, Jeff, Jones, G, Seeman, E
• Format: Article in Journal/Newspaper
• Language: English
• Published: PANGAEA 2009
• Subjects: International Polar Year 2007-2008 IPY; Antarc*; Antarctic; Antarctica; International Polar Year; IPY
• Online Access: https://dx.doi.org/10.1594/pangaea.811580; https://doi.pangaea.de/10.1594/PANGAEA.811580

Summary: Serum 25(OH)D levels decline without sunlight exposure. We studied 120 expeditioners to Antarctica to determine the skeletal and hormonal responses to sunlight deprivation. With emerging vitamin D insufficiency, serum calcium decreased, PTH increased, and bone loss at the proximal femur was observed. Baseline serum 25(OH)D levels >100 nmol/L prevented vitamin D insufficiency. Introduction: Vitamin D stores deplete without adequate sunlight exposure unless supplementation is provided. We studied 120 healthy adults who spent a year in Antarctica as a model for sunlight deprivation to define the timing and magnitude of the skeletal and hormonal responses to emerging vitamin D insufficiency.Methods: Fasting blood samples were assessed at baseline, 6 and 12 months for serum 25-hydroxyvitamin D (25(OH)D), osteocalcin (OC), bone formation (P1NP) and resorption (CTx), PTH and calcium. Lumbar spine and proximal femur BMD was measured using DXA. Differences over time were determined using repeated measures ... : Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 ...