(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ...
Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-...
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Online Access: | https://dx.doi.org/10.1594/pangaea.810387 https://doi.pangaea.de/10.1594/PANGAEA.810387 |
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ftdatacite:10.1594/pangaea.810387 2024-03-31T07:51:15+00:00 (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... Gutleb, Arno C Cenijn, Peter van Velzen, Martin Lie, Elisabeth Ropstad, Erik Skaare, Janneche Utne Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette 2010 text/tab-separated-values https://dx.doi.org/10.1594/pangaea.810387 https://doi.pangaea.de/10.1594/PANGAEA.810387 en eng PANGAEA https://dx.doi.org/10.1021/es903029j Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 Ursus maritimus Sex Age, relative, number of years Age, comment Polychlorinated biphenyl 47 Polychlorinated biphenyl 99 Polychlorinated biphenyl 118 Polychlorinated biphenyl 128 Polychlorinated biphenyl 137 Polychlorinated biphenyl 138 Polychlorinated biphenyl 153 Polychlorinated biphenyl 156 Polychlorinated biphenyl 157 Polychlorinated biphenyl 170 Polychlorinated biphenyl 180 Polychlorinated biphenyl 183 Polychlorinated biphenyl 187 Polychlorinated biphenyl 189 Polychlorinated biphenyl 194 Polychlorinated biphenyl 206 Hydroxy-polychlorinated biphenyl 107 Hydroxy-polychlorinated biphenyl 146 Hydroxy-polychlorinated biphenyl 187 Hydroxylated polybrominated diphenyl ethers 2,4,6-Tribromophenol para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol Hexachlorobenzene alpha-Hexachlorocyclohexane beta-Hexachlorocyclohexane Oxychlordane trans-Nonachlor Biological sample International Polar Year 2007-2008 IPY dataset Dataset Supplementary Dataset 2010 ftdatacite https://doi.org/10.1594/pangaea.81038710.1021/es903029j 2024-03-04T14:13:27Z Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on ... : Concentrations are given per gram wet weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 ... Dataset Arctic International Polar Year IPY Svalbard Ursus maritimus DataCite Metadata Store (German National Library of Science and Technology) Arctic Svalbard |
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Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
Ursus maritimus Sex Age, relative, number of years Age, comment Polychlorinated biphenyl 47 Polychlorinated biphenyl 99 Polychlorinated biphenyl 118 Polychlorinated biphenyl 128 Polychlorinated biphenyl 137 Polychlorinated biphenyl 138 Polychlorinated biphenyl 153 Polychlorinated biphenyl 156 Polychlorinated biphenyl 157 Polychlorinated biphenyl 170 Polychlorinated biphenyl 180 Polychlorinated biphenyl 183 Polychlorinated biphenyl 187 Polychlorinated biphenyl 189 Polychlorinated biphenyl 194 Polychlorinated biphenyl 206 Hydroxy-polychlorinated biphenyl 107 Hydroxy-polychlorinated biphenyl 146 Hydroxy-polychlorinated biphenyl 187 Hydroxylated polybrominated diphenyl ethers 2,4,6-Tribromophenol para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol Hexachlorobenzene alpha-Hexachlorocyclohexane beta-Hexachlorocyclohexane Oxychlordane trans-Nonachlor Biological sample International Polar Year 2007-2008 IPY |
spellingShingle |
Ursus maritimus Sex Age, relative, number of years Age, comment Polychlorinated biphenyl 47 Polychlorinated biphenyl 99 Polychlorinated biphenyl 118 Polychlorinated biphenyl 128 Polychlorinated biphenyl 137 Polychlorinated biphenyl 138 Polychlorinated biphenyl 153 Polychlorinated biphenyl 156 Polychlorinated biphenyl 157 Polychlorinated biphenyl 170 Polychlorinated biphenyl 180 Polychlorinated biphenyl 183 Polychlorinated biphenyl 187 Polychlorinated biphenyl 189 Polychlorinated biphenyl 194 Polychlorinated biphenyl 206 Hydroxy-polychlorinated biphenyl 107 Hydroxy-polychlorinated biphenyl 146 Hydroxy-polychlorinated biphenyl 187 Hydroxylated polybrominated diphenyl ethers 2,4,6-Tribromophenol para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol Hexachlorobenzene alpha-Hexachlorocyclohexane beta-Hexachlorocyclohexane Oxychlordane trans-Nonachlor Biological sample International Polar Year 2007-2008 IPY Gutleb, Arno C Cenijn, Peter van Velzen, Martin Lie, Elisabeth Ropstad, Erik Skaare, Janneche Utne Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
topic_facet |
Ursus maritimus Sex Age, relative, number of years Age, comment Polychlorinated biphenyl 47 Polychlorinated biphenyl 99 Polychlorinated biphenyl 118 Polychlorinated biphenyl 128 Polychlorinated biphenyl 137 Polychlorinated biphenyl 138 Polychlorinated biphenyl 153 Polychlorinated biphenyl 156 Polychlorinated biphenyl 157 Polychlorinated biphenyl 170 Polychlorinated biphenyl 180 Polychlorinated biphenyl 183 Polychlorinated biphenyl 187 Polychlorinated biphenyl 189 Polychlorinated biphenyl 194 Polychlorinated biphenyl 206 Hydroxy-polychlorinated biphenyl 107 Hydroxy-polychlorinated biphenyl 146 Hydroxy-polychlorinated biphenyl 187 Hydroxylated polybrominated diphenyl ethers 2,4,6-Tribromophenol para,para-Dichlorodiphenyldichloroethylene Pentachlorophenol Hexachlorobenzene alpha-Hexachlorocyclohexane beta-Hexachlorocyclohexane Oxychlordane trans-Nonachlor Biological sample International Polar Year 2007-2008 IPY |
description |
Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on ... : Concentrations are given per gram wet weight. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 ... |
format |
Dataset |
author |
Gutleb, Arno C Cenijn, Peter van Velzen, Martin Lie, Elisabeth Ropstad, Erik Skaare, Janneche Utne Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette |
author_facet |
Gutleb, Arno C Cenijn, Peter van Velzen, Martin Lie, Elisabeth Ropstad, Erik Skaare, Janneche Utne Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette |
author_sort |
Gutleb, Arno C |
title |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_short |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_full |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_fullStr |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_full_unstemmed |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_sort |
(table 1) concentration of pcb and other contaminants in blood plasma of polar bears (ursus maritimus) from svalbard ... |
publisher |
PANGAEA |
publishDate |
2010 |
url |
https://dx.doi.org/10.1594/pangaea.810387 https://doi.pangaea.de/10.1594/PANGAEA.810387 |
geographic |
Arctic Svalbard |
geographic_facet |
Arctic Svalbard |
genre |
Arctic International Polar Year IPY Svalbard Ursus maritimus |
genre_facet |
Arctic International Polar Year IPY Svalbard Ursus maritimus |
op_relation |
https://dx.doi.org/10.1021/es903029j |
op_rights |
Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 |
op_doi |
https://doi.org/10.1594/pangaea.81038710.1021/es903029j |
_version_ |
1795029836926812160 |