(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759
The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as...
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PANGAEA - Data Publisher for Earth & Environmental Science
2008
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Online Access: | https://dx.doi.org/10.1594/pangaea.810194 https://doi.pangaea.de/10.1594/PANGAEA.810194 |
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record_format |
openpolar |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
topic |
Sample type Lipids Lipids, standard deviation Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Methyl sulfone polychlorinated biphenyl Methyl sulfone polychlorinated biphenyl, standard deviation Hydroxy-polychlorinated biphenyl Hydroxy-polychlorinated biphenyl, standard deviation Chlordane Chlordane, standard deviation para,para-Dichlorodiphenyldichloroethylene Dichlorodiphenyldichloroethylene, standard deviation 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene Chlorinated benzene Chlorinated benzene, standard deviation Hexachlorocyclohexane Hexachlorocyclohexane, standard deviation Octachlorostyrene Octachlorostyrene, standard deviation Mirex Mirex, standard deviation Dieldrin Dieldrin, standard deviation 4-hydroxy-heptachlorostyrene 4-hydroxy-heptachlorostyrene, standard deviation Pentachlorophenol Pentachlorophenol, standard deviation Polybrominated diphenyl ethers Polybrominated diphenyl ethers, standard deviation alpha-Hexabromocyclododecane Hexabromocyclododecane, standard deviation Hydroxylated polybrominated diphenyl ethers Hydroxylated polybrominated diphenyl ethers, standard deviation Hydroxylated polybrominated biphenyl Hydroxylated polybrominated biphenyl, standard deviation Methoxylated polybrominated diphenyl ethers International Polar Year 2007-2008 IPY |
spellingShingle |
Sample type Lipids Lipids, standard deviation Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Methyl sulfone polychlorinated biphenyl Methyl sulfone polychlorinated biphenyl, standard deviation Hydroxy-polychlorinated biphenyl Hydroxy-polychlorinated biphenyl, standard deviation Chlordane Chlordane, standard deviation para,para-Dichlorodiphenyldichloroethylene Dichlorodiphenyldichloroethylene, standard deviation 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene Chlorinated benzene Chlorinated benzene, standard deviation Hexachlorocyclohexane Hexachlorocyclohexane, standard deviation Octachlorostyrene Octachlorostyrene, standard deviation Mirex Mirex, standard deviation Dieldrin Dieldrin, standard deviation 4-hydroxy-heptachlorostyrene 4-hydroxy-heptachlorostyrene, standard deviation Pentachlorophenol Pentachlorophenol, standard deviation Polybrominated diphenyl ethers Polybrominated diphenyl ethers, standard deviation alpha-Hexabromocyclododecane Hexabromocyclododecane, standard deviation Hydroxylated polybrominated diphenyl ethers Hydroxylated polybrominated diphenyl ethers, standard deviation Hydroxylated polybrominated biphenyl Hydroxylated polybrominated biphenyl, standard deviation Methoxylated polybrominated diphenyl ethers International Polar Year 2007-2008 IPY Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J (Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 |
topic_facet |
Sample type Lipids Lipids, standard deviation Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Methyl sulfone polychlorinated biphenyl Methyl sulfone polychlorinated biphenyl, standard deviation Hydroxy-polychlorinated biphenyl Hydroxy-polychlorinated biphenyl, standard deviation Chlordane Chlordane, standard deviation para,para-Dichlorodiphenyldichloroethylene Dichlorodiphenyldichloroethylene, standard deviation 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene Chlorinated benzene Chlorinated benzene, standard deviation Hexachlorocyclohexane Hexachlorocyclohexane, standard deviation Octachlorostyrene Octachlorostyrene, standard deviation Mirex Mirex, standard deviation Dieldrin Dieldrin, standard deviation 4-hydroxy-heptachlorostyrene 4-hydroxy-heptachlorostyrene, standard deviation Pentachlorophenol Pentachlorophenol, standard deviation Polybrominated diphenyl ethers Polybrominated diphenyl ethers, standard deviation alpha-Hexabromocyclododecane Hexabromocyclododecane, standard deviation Hydroxylated polybrominated diphenyl ethers Hydroxylated polybrominated diphenyl ethers, standard deviation Hydroxylated polybrominated biphenyl Hydroxylated polybrominated biphenyl, standard deviation Methoxylated polybrominated diphenyl ethers International Polar Year 2007-2008 IPY |
description |
The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as SUM-CHL, p,p'-DDE, SUM-CBz, SUM-HCHs, octachlorostyrene (OCS),SUM-mirex, dieldrin, the flame retardants SUM-PBDEs, and total-(R)-hexabromocyclododecane (HBCD), SUM-methylsulfonyl (MeSO2)-PCBs and 3-MeSO2-p,p'-DDE, were found in the adipose and liver tissues relative to whole blood and brain. In contrast, SUM-hydroxyl (OH)-PCB, 4-OH-heptachlorostyrene and SUM-OH-PBDE concentrations were significantly highest (p < 0.05) in whole blood, whereas the highest concentrations of SUM-OH-PBBs were found in the adipose tissue. Based on the total concentrations of all organohalogens in all three tissues and blood, the combined body burden was estimated to be 1.34 ± 0.12 g, where >91% of this amount was accounted for by the adipose tissue alone, followed by the liver, whole blood, and brain. These results show that factors such as protein association and lipid solubility appear to be differentially influencing the toxicokinetics, in terms of tissue composition/localization and burden, of organohalogen classes with respect to chemical structure and properties such as the type of halogenation (e.g., chlorination or bromination), and the presence or absence of additional phenyl group substituents (e.g., MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific. : Sample number is n = 20, unless otherwise indicated.Sum-PCB = CB-28/31,-42,-44,-49,-52,-60,-64/71,-66/95,-70,-74,-84/101,-87,-97,-99,-105,-110,-118,-128,-129/178,-138,-141,-146,-149,-151,-153,-156/171/202,-158,-170/190,-172,-174,-177,-179,-180,-182/187,-183,-194,-195,-196/203,-200,-201,and-206Sum-MeSO2-PCB: 3'/4'-MeSO2-CB49,3/4-MeSO2-CB52,3/4-MeSO2-CB64,3/4-MeSO2-CB70,3'/4'-MeSO2-CB87,3/4-MeSO2-CB91,3'/4'-MeSO2-CB101,3/4-MeSO2-CB110,3'/4'-MeSO2-CB132,3'/4'-MeSO2-CB141,3/4-MeSO2-CB149,3/4-MeSO2-CB174Sum-OH-PCB: 4'-OH-CB79,4-OH-CB97,4'-OH-CB101/4-OH-CB134,4-OH-CB107/4'-OH-CB108,2'-OH-CB114,3-OH-CB118,4'-OH-CB120,4'-OH-CB127,4'-OH-CB130,3'-OH-CB138,4-OH-CB146,4'-OH-CB159,4-OH-CB162,4-OH-CB163,4'-OH-CB172,4'-OH-CB177,4-OH-CB178,3'-OH-CB180,3'-OH-CB182,3'-OH-CB183,3'-OH-CB184,4-OH-CB187,4-OH-CB193,4'-OH-CB199,4'-OH-CB200,4'-OH-CB201,4'-OH-CB202,4,4'-diOH-CB202,3'-OH-CB203/4'-OH-CB198,4'-OH-CB208.Sum-CHL: oxychlordane, frans-chlordane, c/s-chlordane, frans-nonachlor, c/s-nonachlor, heptachlor-epoxide. Sum-CBz: PeCBz, HCB. h 2-HCH: a-, ß-, y-HCH. Sum-PBDE: BDE-17,28,-47,-66,-85,-99,-100,-138,-153,-154,-183,-190,-209. Sum-OH-PBDE: 6'-OH-BDE17, 6'-OH-BDE17, 6'-OH-BDE49, 2'-OH-BDE68, 6-OH-BDE47, 3-OH-BDE47, 5-OH-BDE47, 4'-OH-BDE49, 4-OH-BDE42, 6-OH-BDE90, 6-OH-BDE99, 2-OH-BDE123, 6-OH-BDE85, 6-OH-BDE137.Sum-OH-PBB: one tribrominated and two tetra-brominated OH-PBB. Sum-MeO-PBDE: 4'-MeO-BDE17, 6'-MeO-BDE17, 2'-MeO-BDE28, 4-MeO-BDE42, 3-MeO-BDE47, 5-MeO-BDE47, 6-MeO-BDE47, 4'-MeO-BDE49, 6'-MeO-BDE49, 2'-MeO-BDE68, 6-MeO-BDE85, 6-MeO-BDE90, 6-MeO-BDE99, 2-MeO-BDE123, 6-MeO-BDE137. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 |
format |
Dataset |
author |
Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J |
author_facet |
Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J |
author_sort |
Gebbink, Wouter A |
title |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 |
title_short |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 |
title_full |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 |
title_fullStr |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 |
title_full_unstemmed |
(Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 |
title_sort |
(table 1) concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (ursus maritimus) from east greenland, supplement to: gebbink, wouter a; sonne, christian; dietz, rune; kirkegaard, maja; born, erik w; muir, derek c g; letcher, robert j (2008): target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (ursus maritimus) from east greenland. environmental science & technology, 42(3), 752-759 |
publisher |
PANGAEA - Data Publisher for Earth & Environmental Science |
publishDate |
2008 |
url |
https://dx.doi.org/10.1594/pangaea.810194 https://doi.pangaea.de/10.1594/PANGAEA.810194 |
long_lat |
ENVELOPE(-153.167,-153.167,-86.267,-86.267) |
geographic |
Greenland Dietz |
geographic_facet |
Greenland Dietz |
genre |
East Greenland Greenland International Polar Year IPY Ursus maritimus |
genre_facet |
East Greenland Greenland International Polar Year IPY Ursus maritimus |
op_relation |
https://dx.doi.org/10.1021/es071941f https://dx.doi.org/10.1016/j.envpol.2007.07.001 |
op_rights |
Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 |
op_rightsnorm |
CC-BY |
op_doi |
https://doi.org/10.1594/pangaea.810194 https://doi.org/10.1021/es071941f https://doi.org/10.1016/j.envpol.2007.07.001 |
_version_ |
1766399533463371776 |
spelling |
ftdatacite:10.1594/pangaea.810194 2023-05-15T16:03:51+02:00 (Table 1) Concentrations of neutral and phenolic organohalogen compounds in adipose tissue, blood, brain and liver of polar bears (Ursus maritimus) from East Greenland, supplement to: Gebbink, Wouter A; Sonne, Christian; Dietz, Rune; Kirkegaard, Maja; Born, Erik W; Muir, Derek C G; Letcher, Robert J (2008): Target tissue selectivity and burdens of diverse classes of brominated and chlorinated contaminants in polar bears (Ursus maritimus) from East Greenland. Environmental Science & Technology, 42(3), 752-759 Gebbink, Wouter A Sonne, Christian Dietz, Rune Kirkegaard, Maja Born, Erik W Muir, Derek C G Letcher, Robert J 2008 text/tab-separated-values https://dx.doi.org/10.1594/pangaea.810194 https://doi.pangaea.de/10.1594/PANGAEA.810194 en eng PANGAEA - Data Publisher for Earth & Environmental Science https://dx.doi.org/10.1021/es071941f https://dx.doi.org/10.1016/j.envpol.2007.07.001 Creative Commons Attribution 3.0 Unported https://creativecommons.org/licenses/by/3.0/legalcode cc-by-3.0 CC-BY Sample type Lipids Lipids, standard deviation Polychlorinated biphenyl Polychlorinated biphenyl, standard deviation Methyl sulfone polychlorinated biphenyl Methyl sulfone polychlorinated biphenyl, standard deviation Hydroxy-polychlorinated biphenyl Hydroxy-polychlorinated biphenyl, standard deviation Chlordane Chlordane, standard deviation para,para-Dichlorodiphenyldichloroethylene Dichlorodiphenyldichloroethylene, standard deviation 3-methylsulfonyl p,p-dichlorodiphenyl dichloroethylene Chlorinated benzene Chlorinated benzene, standard deviation Hexachlorocyclohexane Hexachlorocyclohexane, standard deviation Octachlorostyrene Octachlorostyrene, standard deviation Mirex Mirex, standard deviation Dieldrin Dieldrin, standard deviation 4-hydroxy-heptachlorostyrene 4-hydroxy-heptachlorostyrene, standard deviation Pentachlorophenol Pentachlorophenol, standard deviation Polybrominated diphenyl ethers Polybrominated diphenyl ethers, standard deviation alpha-Hexabromocyclododecane Hexabromocyclododecane, standard deviation Hydroxylated polybrominated diphenyl ethers Hydroxylated polybrominated diphenyl ethers, standard deviation Hydroxylated polybrominated biphenyl Hydroxylated polybrominated biphenyl, standard deviation Methoxylated polybrominated diphenyl ethers International Polar Year 2007-2008 IPY Supplementary Dataset dataset Dataset 2008 ftdatacite https://doi.org/10.1594/pangaea.810194 https://doi.org/10.1021/es071941f https://doi.org/10.1016/j.envpol.2007.07.001 2021-11-05T12:55:41Z The tissue-specific composition of sum classes of brominated and chlorinated contaminants and metabolic/degradation byproducts was determined in adult male and female polar bears from East Greenland. Significantly (p < 0.05) higher concentrations of SUM-PCBs, various other organochlorines such as SUM-CHL, p,p'-DDE, SUM-CBz, SUM-HCHs, octachlorostyrene (OCS),SUM-mirex, dieldrin, the flame retardants SUM-PBDEs, and total-(R)-hexabromocyclododecane (HBCD), SUM-methylsulfonyl (MeSO2)-PCBs and 3-MeSO2-p,p'-DDE, were found in the adipose and liver tissues relative to whole blood and brain. In contrast, SUM-hydroxyl (OH)-PCB, 4-OH-heptachlorostyrene and SUM-OH-PBDE concentrations were significantly highest (p < 0.05) in whole blood, whereas the highest concentrations of SUM-OH-PBBs were found in the adipose tissue. Based on the total concentrations of all organohalogens in all three tissues and blood, the combined body burden was estimated to be 1.34 ± 0.12 g, where >91% of this amount was accounted for by the adipose tissue alone, followed by the liver, whole blood, and brain. These results show that factors such as protein association and lipid solubility appear to be differentially influencing the toxicokinetics, in terms of tissue composition/localization and burden, of organohalogen classes with respect to chemical structure and properties such as the type of halogenation (e.g., chlorination or bromination), and the presence or absence of additional phenyl group substituents (e.g., MeO and OH groups). The tissue- and blood-specific accumulation (or retention) among organohalogen classes indicates that exposure and any potential contaminant-mediated effects in these polar bears are likely tissue or blood specific. : Sample number is n = 20, unless otherwise indicated.Sum-PCB = CB-28/31,-42,-44,-49,-52,-60,-64/71,-66/95,-70,-74,-84/101,-87,-97,-99,-105,-110,-118,-128,-129/178,-138,-141,-146,-149,-151,-153,-156/171/202,-158,-170/190,-172,-174,-177,-179,-180,-182/187,-183,-194,-195,-196/203,-200,-201,and-206Sum-MeSO2-PCB: 3'/4'-MeSO2-CB49,3/4-MeSO2-CB52,3/4-MeSO2-CB64,3/4-MeSO2-CB70,3'/4'-MeSO2-CB87,3/4-MeSO2-CB91,3'/4'-MeSO2-CB101,3/4-MeSO2-CB110,3'/4'-MeSO2-CB132,3'/4'-MeSO2-CB141,3/4-MeSO2-CB149,3/4-MeSO2-CB174Sum-OH-PCB: 4'-OH-CB79,4-OH-CB97,4'-OH-CB101/4-OH-CB134,4-OH-CB107/4'-OH-CB108,2'-OH-CB114,3-OH-CB118,4'-OH-CB120,4'-OH-CB127,4'-OH-CB130,3'-OH-CB138,4-OH-CB146,4'-OH-CB159,4-OH-CB162,4-OH-CB163,4'-OH-CB172,4'-OH-CB177,4-OH-CB178,3'-OH-CB180,3'-OH-CB182,3'-OH-CB183,3'-OH-CB184,4-OH-CB187,4-OH-CB193,4'-OH-CB199,4'-OH-CB200,4'-OH-CB201,4'-OH-CB202,4,4'-diOH-CB202,3'-OH-CB203/4'-OH-CB198,4'-OH-CB208.Sum-CHL: oxychlordane, frans-chlordane, c/s-chlordane, frans-nonachlor, c/s-nonachlor, heptachlor-epoxide. Sum-CBz: PeCBz, HCB. h 2-HCH: a-, ß-, y-HCH. Sum-PBDE: BDE-17,28,-47,-66,-85,-99,-100,-138,-153,-154,-183,-190,-209. Sum-OH-PBDE: 6'-OH-BDE17, 6'-OH-BDE17, 6'-OH-BDE49, 2'-OH-BDE68, 6-OH-BDE47, 3-OH-BDE47, 5-OH-BDE47, 4'-OH-BDE49, 4-OH-BDE42, 6-OH-BDE90, 6-OH-BDE99, 2-OH-BDE123, 6-OH-BDE85, 6-OH-BDE137.Sum-OH-PBB: one tribrominated and two tetra-brominated OH-PBB. Sum-MeO-PBDE: 4'-MeO-BDE17, 6'-MeO-BDE17, 2'-MeO-BDE28, 4-MeO-BDE42, 3-MeO-BDE47, 5-MeO-BDE47, 6-MeO-BDE47, 4'-MeO-BDE49, 6'-MeO-BDE49, 2'-MeO-BDE68, 6-MeO-BDE85, 6-MeO-BDE90, 6-MeO-BDE99, 2-MeO-BDE123, 6-MeO-BDE137. Data extracted in the frame of a joint ICSTI/PANGAEA IPY effort, see http://doi.pangaea.de/10.1594/PANGAEA.150150 Dataset East Greenland Greenland International Polar Year IPY Ursus maritimus DataCite Metadata Store (German National Library of Science and Technology) Greenland Dietz ENVELOPE(-153.167,-153.167,-86.267,-86.267) |