Data from: Efficacy of Inactivated and RNA Particle Vaccines in Chickens Against Clade 2.3.4.4b H5 Highly Pathogenic Avian Influenza in North America ...

• Main Authors: Spackman, Erica, Suarez, David L., Lee, Chang-Won, Pantin-Jackwood, Mary J., Lee, Scott A., Youk, Sungsu, Ibrahim, Sherif
• Format: Dataset
• Language: unknown
• Published: Ag Data Commons 2024
• Subjects: Agricultural, veterinary and food sciences; Veterinary sciences; FOS Veterinary sciences; Veterinary virology; Animal production; Animal protection incl. pests and pathogens; Suarez; gyrfalcon
• Online Access: https://dx.doi.org/10.15482/usda.adc/24851658.v1; https://agdatacommons.nal.usda.gov/articles/dataset/Data_from_Efficacy_of_Inactivated_and_RNA_Particle_Vaccines_in_Chickens_Against_Clade_2_3_4_4b_H5_Highly_Pathogenic_Avian_Influenza_in_North_America/24851658/1

Tabulated individual data points for data reported in the associated publication: Spackman E, Suarez DL, Lee CW, Pantin-Jackwood MJ, Lee SA, Youk S, Ibrahim S. Efficacy of inactivated and RNA particle vaccines against a North American Clade 2.3.4.4b H5 highly pathogenic avian influenza virus in chickens. Vaccine. 2023 Nov 30;41(49):7369-7376. doi: 10.1016/j.vaccine.2023.10.070. Epub 2023 Nov 4. PMID: 37932132. Description of methods Viruses The highly pathogenic avian influenza virus (HPAIV) isolate A/turkey/Indiana/22-003707-003/2022 H5N1 (TK/IN/22) and A/Gyrfalcon/Washington/41088/2014 H5N8 (GF/WA/14) isolate were each propagated and titrated in embryonating specific pathogen free (SPF) chicken eggs using standard procedures and titers were determined using the Reed-Muench method. Vaccines An in-house vaccine was produced by de novo synthesizing the HA gene of TK/IN/22 that was modified to be low pathogenic (LP) and placing it in a PR8 backbone using rg methods as described . The vaccine (SEP-22-N9) ...