(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ...
Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-...
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ftdatacite:10.15468/4urteg 2023-12-31T10:03:54+01:00 (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... Gutleb, Arno C Cenijn, Peter Van Velzen, Martin Lie, Elisabeth Ropstad, Erik Janneche Utne Skaare Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette 2010 https://dx.doi.org/10.15468/4urteg https://www.gbif.org/dataset/587c2944-a368-4e65-948a-a2c2f067865a en eng PANGAEA - Publishing Network for Geoscientific and Environmental Data https://dx.doi.org/10.1594/pangaea.810387 Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 Dataset OCCURRENCE dataset 2010 ftdatacite https://doi.org/10.15468/4urteg10.1594/pangaea.810387 2023-12-01T10:29:53Z Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on ... Dataset Arctic Svalbard Ursus maritimus DataCite Metadata Store (German National Library of Science and Technology) |
institution |
Open Polar |
collection |
DataCite Metadata Store (German National Library of Science and Technology) |
op_collection_id |
ftdatacite |
language |
English |
description |
Persistent chemicals accumulate in the arctic environment due to their chemical reactivity and physicochemical properties and polychlorinated biphenyls (PCBs) are the most concentrated pollutant class in polar bears (Ursus maritimus). Metabolism of PCB and polybrominated biphenyl ether (PBDE) flame-retardants alter their toxicological properties and these metabolites are known to interfere with the binding of thyroid hormone (TH) to transthyretin (TTR) in rodents and humans. In polar bear plasma samples no binding of [125I]-T4 to TTR was observed after incubation and PAGE separation. Incubation of the plasma samples with [14C]-4-OH-CB107, a compound with a higher binding affinity to TTR than the endogenous ligand T4 resulted in competitive binding as proven by the appearance of a radio labeled TTR peak in the gel. Plasma incubation with T4 up to 1 mM, a concentration that is not physiologically relevant anymore did not result in any visible competition. These results give evidence that the binding sites on ... |
format |
Dataset |
author |
Gutleb, Arno C Cenijn, Peter Van Velzen, Martin Lie, Elisabeth Ropstad, Erik Janneche Utne Skaare Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette |
spellingShingle |
Gutleb, Arno C Cenijn, Peter Van Velzen, Martin Lie, Elisabeth Ropstad, Erik Janneche Utne Skaare Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette (Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
author_facet |
Gutleb, Arno C Cenijn, Peter Van Velzen, Martin Lie, Elisabeth Ropstad, Erik Janneche Utne Skaare Malmberg, Tina Bergman, Åke Gabrielsen, Geir W Legler, Juliette |
author_sort |
Gutleb, Arno C |
title |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_short |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_full |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_fullStr |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_full_unstemmed |
(Table 1) Concentration of PCB and other contaminants in blood plasma of polar bears (Ursus maritimus) from Svalbard ... |
title_sort |
(table 1) concentration of pcb and other contaminants in blood plasma of polar bears (ursus maritimus) from svalbard ... |
publisher |
PANGAEA - Publishing Network for Geoscientific and Environmental Data |
publishDate |
2010 |
url |
https://dx.doi.org/10.15468/4urteg https://www.gbif.org/dataset/587c2944-a368-4e65-948a-a2c2f067865a |
genre |
Arctic Svalbard Ursus maritimus |
genre_facet |
Arctic Svalbard Ursus maritimus |
op_relation |
https://dx.doi.org/10.1594/pangaea.810387 |
op_rights |
Creative Commons Attribution 4.0 International https://creativecommons.org/licenses/by/4.0/legalcode cc-by-4.0 |
op_doi |
https://doi.org/10.15468/4urteg10.1594/pangaea.810387 |
_version_ |
1786827143428177920 |