Quantification of intrahost genetic diversity of Piscine Orthoreovirus (PRV-1) infecting Atlantic and Chinook salmon ...

• Main Author: Caleta, Jessica Marija
• Format: Text
• Language: English
• Published: University of British Columbia 2022
• Subjects: Atlantic salmon; Salmo salar
• Online Access: https://dx.doi.org/10.14288/1.0395461; https://doi.library.ubc.ca/10.14288/1.0395461

The decline in populations of wild Pacific salmon is of great concern given their importance to Indigenous Peoples of Canada, Pacific Northwest ecosystems, and commercial fisheries. Contagious diseases may contribute to these losses. Piscine orthoreovirus 1 (PRV-1) is a pathogen recently linked to Heart and Skeletal Muscle Inflammation (HSMI) in farmed British Columbian Atlantic salmon (Salmo salar), and jaundice/anemia in Chinook salmon (Oncorhynchus tshawytscha). Characterizing the genetic diversity of PRV-1 is foundational to understanding its relationship with salmon disease. PRV-1 is an RNA virus, and as such undergoes error-prone replication that leads to high mutation rates and pathogenic capacity. Reoviruses (respiratory enteric orphan viruses) are intermittently associated with diseases in a broad number of hosts including reptiles, birds, and humans, where their ability to trigger targeted host immune response is being exploited for oncolytics. While genetic differences in the majority proportion ...