Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ...
In response to stimuli (i.e., salmon mucus) the sea louse, Lepeophtheirus salmonis, produces pharmacologically active substances (prostaglandin E₂, trypsin-like proteases and cathepsin). Lice-derived secretions impair the genetic expression of pro-inflammatory mediators in the commercial salmon-head...
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University of British Columbia
2013
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Online Access: | https://dx.doi.org/10.14288/1.0073752 https://doi.library.ubc.ca/10.14288/1.0073752 |
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ftdatacite:10.14288/1.0073752 2023-08-27T04:08:31+02:00 Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... Lewis, Danielle Lee 2013 https://dx.doi.org/10.14288/1.0073752 https://doi.library.ubc.ca/10.14288/1.0073752 en eng University of British Columbia Text article-journal ScholarlyArticle 2013 ftdatacite https://doi.org/10.14288/1.0073752 2023-08-07T14:24:23Z In response to stimuli (i.e., salmon mucus) the sea louse, Lepeophtheirus salmonis, produces pharmacologically active substances (prostaglandin E₂, trypsin-like proteases and cathepsin). Lice-derived secretions impair the genetic expression of pro-inflammatory mediators in the commercial salmon-head kidney (SHK-1) cell line and head kidney macrophages isolated from Atlantic salmon (Salmo salar); however, effects on the functionality of these cells has not been explored. Related to the development of an inflammatory response, salmon species (Oncorhynchus spp. and Salmo spp.) exhibit differences in infection rates and threshold tolerances to L. salmonis. The objective of this study was to determine if the presence of L. salmonis secretory and excretory products (SEPs) alters the innate immune response of salmon. More specifically, the present study examined if the presence of SEPs altered phagocytic activity and respiratory burst response of salmon macrophages. Phagocytosis assays were performed using SHK-1 ... Text Atlantic salmon Salmo salar DataCite Metadata Store (German National Library of Science and Technology) |
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DataCite Metadata Store (German National Library of Science and Technology) |
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English |
description |
In response to stimuli (i.e., salmon mucus) the sea louse, Lepeophtheirus salmonis, produces pharmacologically active substances (prostaglandin E₂, trypsin-like proteases and cathepsin). Lice-derived secretions impair the genetic expression of pro-inflammatory mediators in the commercial salmon-head kidney (SHK-1) cell line and head kidney macrophages isolated from Atlantic salmon (Salmo salar); however, effects on the functionality of these cells has not been explored. Related to the development of an inflammatory response, salmon species (Oncorhynchus spp. and Salmo spp.) exhibit differences in infection rates and threshold tolerances to L. salmonis. The objective of this study was to determine if the presence of L. salmonis secretory and excretory products (SEPs) alters the innate immune response of salmon. More specifically, the present study examined if the presence of SEPs altered phagocytic activity and respiratory burst response of salmon macrophages. Phagocytosis assays were performed using SHK-1 ... |
format |
Text |
author |
Lewis, Danielle Lee |
spellingShingle |
Lewis, Danielle Lee Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... |
author_facet |
Lewis, Danielle Lee |
author_sort |
Lewis, Danielle Lee |
title |
Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... |
title_short |
Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... |
title_full |
Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... |
title_fullStr |
Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... |
title_full_unstemmed |
Interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from Lepeophtheirus salmonis ... |
title_sort |
interactions between salmon macrophages and pathogenic bacteria in the presence of secretions isolated from lepeophtheirus salmonis ... |
publisher |
University of British Columbia |
publishDate |
2013 |
url |
https://dx.doi.org/10.14288/1.0073752 https://doi.library.ubc.ca/10.14288/1.0073752 |
genre |
Atlantic salmon Salmo salar |
genre_facet |
Atlantic salmon Salmo salar |
op_doi |
https://doi.org/10.14288/1.0073752 |
_version_ |
1775349335823745024 |