Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Ma...
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ftdans:oai:easy.dans.knaw.nl:easy-dataset:99974 2023-07-02T03:31:41+02:00 Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen 2017-12-14T16:37:29.000+01:00 http://nbn-resolving.org/urn:nbn:nl:ui:13-de-kwhk https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:99974 unknown doi:10.5061/dryad.j4h65/1 doi:10.1111/mec.14533 http://nbn-resolving.org/urn:nbn:nl:ui:13-de-kwhk doi:10.5061/dryad.j4h65 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:99974 OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf Life sciences medicine and health care 2017 ftdans https://doi.org/10.5061/dryad.j4h65/110.1111/mec.1453310.5061/dryad.j4h65 2023-06-13T13:26:07Z Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Many anticipatory changes in physiology occur before migration to sea, but little is known about the molecular nature of these changes. Here we use a long term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh- and saltwater. We find that lipid metabolism is highly plastic in response to differences in dietary lipid composition in freshwater, but then undergoes a marked shift when salmon transitions to the marine life-stage. Expression of genes in liver relating to lipogenesis and lipid transport decrease overall and become less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid specific whole-genome duplication on lipid metabolism reveals several pathways with significantly different (p<0.05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole genome duplication has resulted in an increased gene dosage. Our results demonstrate the presence of a life-stage associated remodeling of lipid metabolism at the gene regulatory level, suggesting an evolved preparatory optimization of lipid metabolism Other/Unknown Material Atlantic salmon Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
institution |
Open Polar |
collection |
Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
op_collection_id |
ftdans |
language |
unknown |
topic |
Life sciences medicine and health care |
spellingShingle |
Life sciences medicine and health care Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
topic_facet |
Life sciences medicine and health care |
description |
Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens, and shift in dietary lipid availability. Many anticipatory changes in physiology occur before migration to sea, but little is known about the molecular nature of these changes. Here we use a long term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh- and saltwater. We find that lipid metabolism is highly plastic in response to differences in dietary lipid composition in freshwater, but then undergoes a marked shift when salmon transitions to the marine life-stage. Expression of genes in liver relating to lipogenesis and lipid transport decrease overall and become less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid specific whole-genome duplication on lipid metabolism reveals several pathways with significantly different (p<0.05) duplicate retention or duplicate regulatory conservation. We also find a limited number of cases where the whole genome duplication has resulted in an increased gene dosage. Our results demonstrate the presence of a life-stage associated remodeling of lipid metabolism at the gene regulatory level, suggesting an evolved preparatory optimization of lipid metabolism |
author |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen |
author_facet |
Gillard, Gareth Harvey, Thomas N. Gjuvsland, Arne Jin, Yang Thomassen, Magny Lien, Sigbjorn Leaver, Michael Torgersen, Jacob S. Hvidsten, Torgeir R. Vik, Jon Olav Sandve, Simen |
author_sort |
Gillard, Gareth |
title |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_short |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_full |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_fullStr |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_full_unstemmed |
Data from: Life-stage associated remodeling of lipid metabolism regulation in Atlantic salmon |
title_sort |
data from: life-stage associated remodeling of lipid metabolism regulation in atlantic salmon |
publishDate |
2017 |
url |
http://nbn-resolving.org/urn:nbn:nl:ui:13-de-kwhk https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:99974 |
genre |
Atlantic salmon |
genre_facet |
Atlantic salmon |
op_relation |
doi:10.5061/dryad.j4h65/1 doi:10.1111/mec.14533 http://nbn-resolving.org/urn:nbn:nl:ui:13-de-kwhk doi:10.5061/dryad.j4h65 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:99974 |
op_rights |
OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf |
op_doi |
https://doi.org/10.5061/dryad.j4h65/110.1111/mec.1453310.5061/dryad.j4h65 |
_version_ |
1770271071363137536 |