Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas....
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ftdans:oai:easy.dans.knaw.nl:easy-dataset:96491 2023-07-02T03:32:03+02:00 Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng 2017-01-12T22:21:29.000+01:00 http://nbn-resolving.org/urn:nbn:nl:ui:13-m4-h3ot https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:96491 unknown doi:10.5061/dryad.7d6c5/1 doi:10.1098/rsob.160289 http://nbn-resolving.org/urn:nbn:nl:ui:13-m4-h3ot doi:10.5061/dryad.7d6c5 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:96491 OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf Life sciences medicine and health care 2017 ftdans https://doi.org/10.5061/dryad.7d6c5/110.1098/rsob.16028910.5061/dryad.7d6c5 2023-06-13T13:24:06Z The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the ‘nervous-haemocyte’ NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. Other/Unknown Material Crassostrea gigas Pacific oyster Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) Pacific |
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Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
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ftdans |
language |
unknown |
topic |
Life sciences medicine and health care |
spellingShingle |
Life sciences medicine and health care Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
topic_facet |
Life sciences medicine and health care |
description |
The neuroendocrine-immune (NEI) regulatory network is a complex system, which plays an indispensable role in the immunity of host. In this study, a neuroendocrine immunomodulatory axis (NIA)-like pathway mediated by the nervous system and haemocytes was characterized in the oyster Crassostrea gigas. Once invaded pathogen was recognized by the host, the nervous system would temporally release neurotransmitters to modulate the immune response. Instead of acting passively, oyster haemocytes were able to mediate neuronal immunomodulation promptly by controlling the expression of specific neurotransmitter receptors on cell surface and modulating their binding sensitivities, thus regulating intracellular concentration of Ca2+. This neural immunomodulation mediated by the nervous system and haemocytes could influence cellular immunity in oyster by affecting mRNA expression level of TNF genes, and humoral immunity by affecting the activities of key immune-related enzymes. In summary, though simple in structure, the ‘nervous-haemocyte’ NIA-like pathway regulates both cellular and humoral immunity in oyster, meaning a world to the effective immune regulation of the NEI network. |
author |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_facet |
Liu, Zhaoqun Zhou, Zhi Jiang, Qiufen Wang, Lingling Yi, Qilin Qiu, Limei Song, Linsheng |
author_sort |
Liu, Zhaoqun |
title |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_short |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_fullStr |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_full_unstemmed |
Data from: The neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster Crassostrea gigas |
title_sort |
data from: the neuroendocrine immunomodulatory axis-like pathway mediated by circulating haemocytes in pacific oyster crassostrea gigas |
publishDate |
2017 |
url |
http://nbn-resolving.org/urn:nbn:nl:ui:13-m4-h3ot https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:96491 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
doi:10.5061/dryad.7d6c5/1 doi:10.1098/rsob.160289 http://nbn-resolving.org/urn:nbn:nl:ui:13-m4-h3ot doi:10.5061/dryad.7d6c5 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:96491 |
op_rights |
OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf |
op_doi |
https://doi.org/10.5061/dryad.7d6c5/110.1098/rsob.16028910.5061/dryad.7d6c5 |
_version_ |
1770271515870232576 |