Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis)
Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene...
Main Authors: | , , |
---|---|
Language: | unknown |
Published: |
2015
|
Subjects: | |
Online Access: | http://nbn-resolving.org/urn:nbn:nl:ui:13-98-y5t6 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:91297 |
id |
ftdans:oai:easy.dans.knaw.nl:easy-dataset:91297 |
---|---|
record_format |
openpolar |
spelling |
ftdans:oai:easy.dans.knaw.nl:easy-dataset:91297 2023-07-02T03:34:00+02:00 Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. 2015-10-29T17:43:18.000+01:00 http://nbn-resolving.org/urn:nbn:nl:ui:13-98-y5t6 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:91297 unknown doi:10.5061/dryad.h43c1/1 doi:10.1186/s12863-015-0284-y PMID:26503624 http://nbn-resolving.org/urn:nbn:nl:ui:13-98-y5t6 doi:10.5061/dryad.h43c1 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:91297 OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf Life sciences medicine and health care 2015 ftdans https://doi.org/10.5061/dryad.h43c1/110.1186/s12863-015-0284-y10.5061/dryad.h43c1 2023-06-13T13:20:28Z Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods: To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results: We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions: Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. Other/Unknown Material Lynx Lynx lynx lynx Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) Canada |
institution |
Open Polar |
collection |
Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
op_collection_id |
ftdans |
language |
unknown |
topic |
Life sciences medicine and health care |
spellingShingle |
Life sciences medicine and health care Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
topic_facet |
Life sciences medicine and health care |
description |
Background: The androgen receptor, an X-linked gene, has been widely studied in human populations because it contains highly polymorphic trinucleotide repeat motifs that have been associated with a number of adverse human health and behavioral effects. A previous study on the androgen receptor gene in carnivores reported somatic mosaicism in the tissues of a number of species including Eurasian lynx (Lynx lynx). We investigated this claim in a closely related species, Canada lynx (Lynx canadensis). The presence of somatic mosaicism in lynx tissues could have implications for the future study of exonic trinucleotide repeats in landscape genomic studies, in which the accurate reporting of genotypes would be highly problematic. Methods: To determine whether mosaicism occurs in Canada lynx, two lynx individuals were sampled for a variety of tissue types (lynx 1) and tissue locations (lynx 1 and 2), and 1,672 individuals of known sex were genotyped to further rule out mosaicism. Results: We found no evidence of mosaicism in tissues from the two necropsied individuals, or any of our genotyped samples. Conclusions: Our results indicate that mosaicism does not manifest in Canada lynx. Therefore, the use of hide samples for further work involving trinucleotide repeat polymorphisms in Canada lynx is warranted. |
author |
Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. |
author_facet |
Prentice, Melanie B. Bowman, Jeff Wilson, Paul J. |
author_sort |
Prentice, Melanie B. |
title |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_short |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_fullStr |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_full_unstemmed |
Data from: A test of somatic mosaicism in the androgen receptor gene of Canada lynx (Lynx canadensis) |
title_sort |
data from: a test of somatic mosaicism in the androgen receptor gene of canada lynx (lynx canadensis) |
publishDate |
2015 |
url |
http://nbn-resolving.org/urn:nbn:nl:ui:13-98-y5t6 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:91297 |
geographic |
Canada |
geographic_facet |
Canada |
genre |
Lynx Lynx lynx lynx |
genre_facet |
Lynx Lynx lynx lynx |
op_relation |
doi:10.5061/dryad.h43c1/1 doi:10.1186/s12863-015-0284-y PMID:26503624 http://nbn-resolving.org/urn:nbn:nl:ui:13-98-y5t6 doi:10.5061/dryad.h43c1 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:91297 |
op_rights |
OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf |
op_doi |
https://doi.org/10.5061/dryad.h43c1/110.1186/s12863-015-0284-y10.5061/dryad.h43c1 |
_version_ |
1770274271494406144 |