Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird
Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is...
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ftdans:oai:easy.dans.knaw.nl:easy-dataset:84815 2023-07-02T03:33:47+02:00 Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird Bauch, Christina Becker, Peter H. Verhulst, Simon 2013-12-09T18:43:01.000+01:00 http://nbn-resolving.org/urn:nbn:nl:ui:13-tj-yxgh https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:84815 unknown doi:10.5061/dryad.k8r75/1 doi:10.1111/mec.12602 PMID:24274429 http://nbn-resolving.org/urn:nbn:nl:ui:13-tj-yxgh doi:10.5061/dryad.k8r75 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:84815 OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf Life sciences medicine and health care 2013 ftdans https://doi.org/10.5061/dryad.k8r75/110.1111/mec.1260210.5061/dryad.k8r75 2023-06-13T12:37:30Z Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere-induced cell senescence. Other/Unknown Material Sterna hirundo Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
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Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
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Life sciences medicine and health care |
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Life sciences medicine and health care Bauch, Christina Becker, Peter H. Verhulst, Simon Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
topic_facet |
Life sciences medicine and health care |
description |
Telomeres, DNA-protein structures at chromosome ends, shorten with age, and telomere length has been linked to age-related diseases and survival. In vitro studies revealed that the shortest telomeres trigger cell senescence, but whether the shortest telomeres are also the best biomarker of ageing is not known. We measured telomeres in erythrocytes of wild common terns Sterna hirundo using terminal restriction fragment analysis. This yields a distribution of telomere lengths for each sample, and we investigated how different telomere subpopulations (percentiles) varied in their relation to age and fitness proxies. Longer telomeres within a genome lost more base pairs with age and were better predictors of survival than shorter telomeres. Likewise, fitness proxies such as arrival date at the breeding grounds and reproductive success were best predicted by telomere length at the higher percentiles. Our finding that longer telomeres within a genome predict fitness components better than the shorter telomeres indicates that they are a more informative ageing biomarker. This finding contrasts with the fact that cell senescence is triggered by the shortest telomeres. We suggest that this paradox arises, because longer telomeres lose more base pairs per unit time and thus better reflect the various forms of stress that accelerate telomere shortening, and that telomeres primarily function as biomarker because their shortening reflects cumulative effects of various stressors rather than reflecting telomere-induced cell senescence. |
author |
Bauch, Christina Becker, Peter H. Verhulst, Simon |
author_facet |
Bauch, Christina Becker, Peter H. Verhulst, Simon |
author_sort |
Bauch, Christina |
title |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_short |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_full |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_fullStr |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_full_unstemmed |
Data from: Within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
title_sort |
data from: within the genome, long telomeres are more informative than short telomeres with respect to fitness components in a long-lived seabird |
publishDate |
2013 |
url |
http://nbn-resolving.org/urn:nbn:nl:ui:13-tj-yxgh https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:84815 |
genre |
Sterna hirundo |
genre_facet |
Sterna hirundo |
op_relation |
doi:10.5061/dryad.k8r75/1 doi:10.1111/mec.12602 PMID:24274429 http://nbn-resolving.org/urn:nbn:nl:ui:13-tj-yxgh doi:10.5061/dryad.k8r75 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:84815 |
op_rights |
OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf |
op_doi |
https://doi.org/10.5061/dryad.k8r75/110.1111/mec.1260210.5061/dryad.k8r75 |
_version_ |
1770273882545061888 |