Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas
The deleterious effects of inbreeding are well documented and of major concern in conservation biology. Stressful environments have generally been shown to increase inbreeding depression; however, little is known about the underlying genetic mechanisms of the inbreeding-by-stress interaction and to...
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ftdans:oai:easy.dans.knaw.nl:easy-dataset:81882 2023-07-02T03:32:03+02:00 Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas Plough, Louis V. 2012-05-25T18:22:19.000+02:00 http://nbn-resolving.org/urn:nbn:nl:ui:13-dd-92zb https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:81882 unknown doi:10.5061/dryad.376jg/1 doi:10.1111/j.1365-294X.2012.05688.x PMID:22747636 http://nbn-resolving.org/urn:nbn:nl:ui:13-dd-92zb doi:10.5061/dryad.376jg https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:81882 OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf Life sciences medicine and health care 2012 ftdans https://doi.org/10.5061/dryad.376jg/110.1111/j.1365-294X.2012.05688.x10.5061/dryad.376jg 2023-06-13T13:03:20Z The deleterious effects of inbreeding are well documented and of major concern in conservation biology. Stressful environments have generally been shown to increase inbreeding depression; however, little is known about the underlying genetic mechanisms of the inbreeding-by-stress interaction and to what extent the fitness of individual deleterious mutations is altered under stress. Using microsatellite marker segregation data and quantitative trait locus (QTL) mapping methods, I performed a genome scan for deleterious mutations affecting viability (viability or vQTL) in two, inbred families of the Pacific oyster Crassostrea gigas, reared in a stressful, nutrient-poor diet and a favorable, nutrient-rich diet, which had significant effects on growth and survival. Twice as many vQTL were detected in the stressful diet compared with the favorable diet, resulting primarily from substantially greater mortality of homozygous genotypes. At vQTL, estimates of selection (s) and dominance (h) were significantly greater in the stressful environment (s ̅ = 0.86 vs. 0.54 and h ̅ = 0.35 vs. 0.18, in stressful and non-stressful diets, respectively). There was no evidence of interaction between vQTL. Individual vQTL differed across diets in selection only, or in both selection and dominance, and some vQTL were not affected by diet. These results suggest that stress-associated increases in selection against individual deleterious alleles underlie greater inbreeding depression with stress. Furthermore, the finding that inbreeding-by-environment interaction appears, to some extent, to be locus-specific, helps to explain previous observations of lineage-specific expression of inbreeding depression and environment-specific purging, which have important implications for conservation and evolutionary biology. Other/Unknown Material Crassostrea gigas Pacific oyster Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) Pacific |
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Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
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ftdans |
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Life sciences medicine and health care |
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Life sciences medicine and health care Plough, Louis V. Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
topic_facet |
Life sciences medicine and health care |
description |
The deleterious effects of inbreeding are well documented and of major concern in conservation biology. Stressful environments have generally been shown to increase inbreeding depression; however, little is known about the underlying genetic mechanisms of the inbreeding-by-stress interaction and to what extent the fitness of individual deleterious mutations is altered under stress. Using microsatellite marker segregation data and quantitative trait locus (QTL) mapping methods, I performed a genome scan for deleterious mutations affecting viability (viability or vQTL) in two, inbred families of the Pacific oyster Crassostrea gigas, reared in a stressful, nutrient-poor diet and a favorable, nutrient-rich diet, which had significant effects on growth and survival. Twice as many vQTL were detected in the stressful diet compared with the favorable diet, resulting primarily from substantially greater mortality of homozygous genotypes. At vQTL, estimates of selection (s) and dominance (h) were significantly greater in the stressful environment (s ̅ = 0.86 vs. 0.54 and h ̅ = 0.35 vs. 0.18, in stressful and non-stressful diets, respectively). There was no evidence of interaction between vQTL. Individual vQTL differed across diets in selection only, or in both selection and dominance, and some vQTL were not affected by diet. These results suggest that stress-associated increases in selection against individual deleterious alleles underlie greater inbreeding depression with stress. Furthermore, the finding that inbreeding-by-environment interaction appears, to some extent, to be locus-specific, helps to explain previous observations of lineage-specific expression of inbreeding depression and environment-specific purging, which have important implications for conservation and evolutionary biology. |
author |
Plough, Louis V. |
author_facet |
Plough, Louis V. |
author_sort |
Plough, Louis V. |
title |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_short |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_full |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_fullStr |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_full_unstemmed |
Data from: Environmental stress increases selection against and dominance of deleterious mutations in inbred families of the Pacific oyster Crassostrea gigas |
title_sort |
data from: environmental stress increases selection against and dominance of deleterious mutations in inbred families of the pacific oyster crassostrea gigas |
publishDate |
2012 |
url |
http://nbn-resolving.org/urn:nbn:nl:ui:13-dd-92zb https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:81882 |
geographic |
Pacific |
geographic_facet |
Pacific |
genre |
Crassostrea gigas Pacific oyster |
genre_facet |
Crassostrea gigas Pacific oyster |
op_relation |
doi:10.5061/dryad.376jg/1 doi:10.1111/j.1365-294X.2012.05688.x PMID:22747636 http://nbn-resolving.org/urn:nbn:nl:ui:13-dd-92zb doi:10.5061/dryad.376jg https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:81882 |
op_rights |
OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf |
op_doi |
https://doi.org/10.5061/dryad.376jg/110.1111/j.1365-294X.2012.05688.x10.5061/dryad.376jg |
_version_ |
1770271523375939584 |