Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska
For pathogens that infect multiple species the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We test the hypothesis that rabies virus variant distribution corresponds to the...
Main Authors: | , , , , , |
---|---|
Language: | unknown |
Published: |
2015
|
Subjects: | |
Online Access: | http://nbn-resolving.org/urn:nbn:nl:ui:13-w9-pbpw https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:118632 |
id |
ftdans:oai:easy.dans.knaw.nl:easy-dataset:118632 |
---|---|
record_format |
openpolar |
spelling |
ftdans:oai:easy.dans.knaw.nl:easy-dataset:118632 2023-07-02T03:30:57+02:00 Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten 2015-12-02T16:48:38.000+01:00 http://nbn-resolving.org/urn:nbn:nl:ui:13-w9-pbpw https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:118632 unknown doi:10.5061/dryad.dc1q8.1/2.1 http://nbn-resolving.org/urn:nbn:nl:ui:13-w9-pbpw doi:10.5061/dryad.dc1q8.1 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:118632 OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf Life sciences medicine and health care 2015 ftdans https://doi.org/10.5061/dryad.dc1q8.1/2.110.5061/dryad.dc1q8.1 2023-06-13T13:34:26Z For pathogens that infect multiple species the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We test the hypothesis that rabies virus variant distribution corresponds to the population structure of the primary rabies hosts in Alaska, arctic foxes (Vulpes lagopus) and red foxes (V. vulpes) in order to possibly distinguish reservoir and spill over hosts. We used mitochondrial DNA (mtDNA) sequence and nine microsatellites to assess population structure in those two species. mtDNA structure did not correspond to rabies virus variant structure in either species. Microsatellite analyses gave varying results. Bayesian clustering found 2 groups of arctic foxes in the coastal tundra region, but for red foxes it identified tundra and boreal types. Spatial Bayesian clustering and spatial principal components analysis identified 3 and 4 groups of arctic foxes, respectively, closely matching the distribution of rabies virus variants in the state. Red foxes, conversely, showed eight clusters comprising 2 regions (boreal and tundra) with much admixture. These results run contrary to previous beliefs that arctic fox show no fine-scale spatial population structure. While we cannot rule out that the red fox is part of the maintenance host community for rabies in Alaska, the distribution of virus variants appears to be driven primarily by the artic fox Therefore we show that host population genetics can be utilized to distinguish between maintenance and spillover hosts when used in conjunction with other approaches. Other/Unknown Material Arctic Fox Arctic Tundra Vulpes lagopus Alaska Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) Arctic |
institution |
Open Polar |
collection |
Data Archiving and Networked Services (DANS): EASY (KNAW - Koninklijke Nederlandse Akademie van Wetenschappen) |
op_collection_id |
ftdans |
language |
unknown |
topic |
Life sciences medicine and health care |
spellingShingle |
Life sciences medicine and health care Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
topic_facet |
Life sciences medicine and health care |
description |
For pathogens that infect multiple species the distinction between reservoir hosts and spillover hosts is often difficult. In Alaska, three variants of the arctic rabies virus exist with distinct spatial distributions. We test the hypothesis that rabies virus variant distribution corresponds to the population structure of the primary rabies hosts in Alaska, arctic foxes (Vulpes lagopus) and red foxes (V. vulpes) in order to possibly distinguish reservoir and spill over hosts. We used mitochondrial DNA (mtDNA) sequence and nine microsatellites to assess population structure in those two species. mtDNA structure did not correspond to rabies virus variant structure in either species. Microsatellite analyses gave varying results. Bayesian clustering found 2 groups of arctic foxes in the coastal tundra region, but for red foxes it identified tundra and boreal types. Spatial Bayesian clustering and spatial principal components analysis identified 3 and 4 groups of arctic foxes, respectively, closely matching the distribution of rabies virus variants in the state. Red foxes, conversely, showed eight clusters comprising 2 regions (boreal and tundra) with much admixture. These results run contrary to previous beliefs that arctic fox show no fine-scale spatial population structure. While we cannot rule out that the red fox is part of the maintenance host community for rabies in Alaska, the distribution of virus variants appears to be driven primarily by the artic fox Therefore we show that host population genetics can be utilized to distinguish between maintenance and spillover hosts when used in conjunction with other approaches. |
author |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten |
author_facet |
Goldsmith, Elizabeth W. Renshaw, Benjamin Clement, Christopher J. Himschoot, Elizabeth A. Hundertmark, Kris J. Hueffer, Karsten |
author_sort |
Goldsmith, Elizabeth W. |
title |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_short |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_full |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_fullStr |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_full_unstemmed |
Data from: Population structure of two rabies hosts relative to the known distribution of rabies virus variants in Alaska |
title_sort |
data from: population structure of two rabies hosts relative to the known distribution of rabies virus variants in alaska |
publishDate |
2015 |
url |
http://nbn-resolving.org/urn:nbn:nl:ui:13-w9-pbpw https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:118632 |
geographic |
Arctic |
geographic_facet |
Arctic |
genre |
Arctic Fox Arctic Tundra Vulpes lagopus Alaska |
genre_facet |
Arctic Fox Arctic Tundra Vulpes lagopus Alaska |
op_relation |
doi:10.5061/dryad.dc1q8.1/2.1 http://nbn-resolving.org/urn:nbn:nl:ui:13-w9-pbpw doi:10.5061/dryad.dc1q8.1 https://easy.dans.knaw.nl/ui/datasets/id/easy-dataset:118632 |
op_rights |
OPEN_ACCESS: The data are archived in Easy, they are accessible elsewhere through the DOI https://dans.knaw.nl/en/about/organisation-and-policy/legal-information/DANSLicence.pdf |
op_doi |
https://doi.org/10.5061/dryad.dc1q8.1/2.110.5061/dryad.dc1q8.1 |
_version_ |
1770275211598364672 |