Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry recep...
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ftczacademyscien:oai:asep.lib.cas.cz:CavUnEpca/0484026 2024-09-15T18:30:25+00:00 Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans Stejskalová, K. Bayerova, Z. Futas, J. Hrazdilová, K. Klumplerova, M. Oppelt, J. Šplíchalová, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.M. Ursache, T. D. Modrý, D. (David) Horin, P. 2017 https://doi.org/10.1111/tan.13146 http://hdl.handle.net/11104/0279187 eng eng info:eu-repo/semantics/altIdentifier/pmid/28892257 doi:10.1111/tan.13146 urn:pissn: 2059-2302 urn:eissn: 2059-2310 http://hdl.handle.net/11104/0279187 Cetacea haplotype immunity innate mhc-dqb Phocoena phocoena polymorphism single nucleotide Stenella coeruleoalba info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion 2017 ftczacademyscien https://doi.org/10.1111/tan.13146 2024-08-19T05:33:01Z Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus-related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3, 7, 8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. Article in Journal/Newspaper Phocoena phocoena The Czech Academy of Sciences: Publication Activity (ASEP) HLA 90 6 343 353 |
institution |
Open Polar |
collection |
The Czech Academy of Sciences: Publication Activity (ASEP) |
op_collection_id |
ftczacademyscien |
language |
English |
topic |
Cetacea haplotype immunity innate mhc-dqb Phocoena phocoena polymorphism single nucleotide Stenella coeruleoalba |
spellingShingle |
Cetacea haplotype immunity innate mhc-dqb Phocoena phocoena polymorphism single nucleotide Stenella coeruleoalba Stejskalová, K. Bayerova, Z. Futas, J. Hrazdilová, K. Klumplerova, M. Oppelt, J. Šplíchalová, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.M. Ursache, T. D. Modrý, D. (David) Horin, P. Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
topic_facet |
Cetacea haplotype immunity innate mhc-dqb Phocoena phocoena polymorphism single nucleotide Stenella coeruleoalba |
description |
Morbilliviruses, such as Cetacean morbillivirus (CeMV) or Phocine distemper virus (PDV), represent a growing threat for marine mammals on both hemispheres. Because free-ranging animal populations strongly rely on natural resistance mechanisms, innate immunity-related genes and virus cell entry receptor genes may represent key factors involved in susceptibility to CeMV in Cetaceans. Using the next generation sequencing technology, we have sequenced 11 candidate genes in two model species, Stenella coeruleoalba and Phocoena phocoena. Suitable single nucleotide polymorphism markers of potential functional importance, located in genes coding for basigin (BSG, CD147), the signaling lymphocyte activating molecule (SLAMF1), the poliovirus-related receptor-4 (NECTIN4, PVRL4), toll-like receptors 3, 7, 8 (TLR3, TLR7, TLR8), natural resistance-associated macrophage protein (SLC11A1) and natural cytotoxicity triggering receptor 1 (NCR1), were identified in each model species, along with MHC-DQB haplotypes unique for each species. This set of molecular markers represents a potentially useful tool for studying host genetic variation and susceptibility to morbillivirus infection in Cetaceans as well as for studying functionally important genetic diversity of selected Cetacean populations. |
format |
Article in Journal/Newspaper |
author |
Stejskalová, K. Bayerova, Z. Futas, J. Hrazdilová, K. Klumplerova, M. Oppelt, J. Šplíchalová, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.M. Ursache, T. D. Modrý, D. (David) Horin, P. |
author_facet |
Stejskalová, K. Bayerova, Z. Futas, J. Hrazdilová, K. Klumplerova, M. Oppelt, J. Šplíchalová, P. Di Guardo, G. Mazzariol, S. Di Francesco, C. E. Di Francesco, G. Terracciano, G. Paiu, R.M. Ursache, T. D. Modrý, D. (David) Horin, P. |
author_sort |
Stejskalová, K. |
title |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_short |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_full |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_fullStr |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_full_unstemmed |
Candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded Cetaceans |
title_sort |
candidate gene molecular markers as tools for analyzing genetic susceptibility to morbillivirus infection in stranded cetaceans |
publishDate |
2017 |
url |
https://doi.org/10.1111/tan.13146 http://hdl.handle.net/11104/0279187 |
genre |
Phocoena phocoena |
genre_facet |
Phocoena phocoena |
op_relation |
info:eu-repo/semantics/altIdentifier/pmid/28892257 doi:10.1111/tan.13146 urn:pissn: 2059-2302 urn:eissn: 2059-2310 http://hdl.handle.net/11104/0279187 |
op_doi |
https://doi.org/10.1111/tan.13146 |
container_title |
HLA |
container_volume |
90 |
container_issue |
6 |
container_start_page |
343 |
op_container_end_page |
353 |
_version_ |
1810471886746812416 |